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A study in Nature Biotechnology investigated context-specific host–microorganisms interactions by using spatial transcriptomics to profile gene expression of host and microbial genes simultaneously.
Inhibition of adrenergic receptors following a traumatic brain injury reduces cerebral oedema and inflammation by restoring fluid efflux through the glymphatic and lymphatic systems.
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the central nervous system can affect the peripheral immune system.
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to the pathogenesis of osteoarthritis and rheumatoid arthritis.
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory responses by sequestering IL-1 to prevent T cell activation.
Gary Koretzky, who was president of the American Association of Immunologists from 2021 to 2022, shares his thoughts on the responsibility of scientists to make science more accessible to a broad public, and reflects on lessons learned during the pandemic.
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiplexed imaging of intact tissues.