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A preprint by Jerby-Arnon et al. uses a novel algorithm for scRNAseq data to describe a pan-cancer programme for dysfunctional tumour-infiltrating lymphocytes that predicts response to immune checkpoint blockade therapy.
The RNA helicase DDX17 is identified as the sensor for a non-canonical NLRC4–NLRP3 inflammasome activated by endogenous retrotransposons in sterile inflammation.
This study links the complement-mediated retraction of T helper 1 cell responses to vitamin D receptor signalling, an autoregulatory loop that might be impaired in patients with COVID-19.
A preprint by Sanin et al. establishes a transcriptional framework to define common macrophage activation states across tissues and biological conditions.
A preprint by Kersten et al. describes a positive-feedback loop promoting the mutual formation of tumour-associated macrophages and exhausted T cells as they move towards the tumour core.
Transient skin inflammation in early life leads to the development of T helper 2 cell–fibroblast niches that alter wound repair responses and may drive fibrotic pathology later in life.
Black In Immuno harnesses social media and digital platforms to connect Black immunologists with one another and with the rest of the scientific ecosystem. We invite you to join us, to connect with and amplify Black immunologists, and to contribute to creating a more inclusive and innovative biomedical community.
Correspondence regarding the Review ‘Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?'
Genetic variants in apolipoprotein L1 (APOL1) — present only in individuals of African ancestry — contribute to increased susceptibility to sepsis and COVID-19. APOL1 variants impair mitophagy in endothelial cells, allowing the release of mitochondrial DNA that activates inflammasome and nucleotide sensing pathways.