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Intestinal ILC3s produce the epidermal growth factor family mediator HB-EGF, which protects the intestinal barrier against TNF-induced epithelial cell death.
A preprint by Ukita et al. describes a role for CXCL13-producing T helper cells in promoting the formation of tertiary lymphoid structures in ovarian cancer that are associated with improved clinical outcome.
At the population level we are seeing milder disease during the Omicron wave of the SARS-CoV-2 pandemic. Is this due to the virus or pre-existing immunity, and what should we expect next?
The transcription factor NFAT acts as a checkpoint in activated platelets to control their aggregation and interaction with neutrophils, keeping thrombotic and inflammatory responses in check.
In this Comment article, Florent Ginhoux, Martin Guilliams and Miriam Merad call for a revised nomenclature of the dendritic cell (DC) lineage to distinguish between DC subsets and DC states and resolve confusion in the light of single-cell transcriptional profiling results.
Less than a month after the sequence of the SARS-CoV-2 Omicron variant was first announced, a number of articles in Nature and Cell examine its immune evasion characteristics.
