News & Comment

Binding of the mucus component mucin 2 to intestinal dendritic cells delivers immunoregulatory signals.

A novel population of CD301b⁺ dendritic cells potentiates T_H2-type immune responses.

Ageing predisposes individuals to macrophage- and TNF-dependent intolerance of cancer immunotherapy.

The presence of memory T_FHcells in the blood correlates with the development of broadly neutralizing antibodies against HIV.

Type 2 ILCs respond to metabolic cues and tune eosinophil numbers to the circadian clock.

Zinc fingers 1 and 4 of the Ikaros protein have differential roles in lymphocyte development and in lymphomagenesis.

A FOXO3-dependent pathway that limits inflammation is associated with disease prognosis in humans.

Intracellular LPS triggers non-canonical inflammasome activation of caspase 11.

Lineage tracing on the basis of DNGR1 expression history defines cells of the conventional DC lineage.

Early development of B cells can occur in the gut in response to resident microorganisms.

The metabolic regulator AMPK controls macrophage skewing during muscle repair.

Lung dendritic cells imprint CD4⁺T cells with lung-homing and gut-homing receptors.

Oxidative damage to self and foreign DNA potentiates its detection by the innate immune system.

TLR4 activation by fibrinogen cleavage products may contribute to allergic airway inflammation.

Pain associated with acute bacterial infection is not secondary to immune activation but is directly induced by bacteria themselves.

Here, the authors present a new theoretical framework — the discontinuity theory — to account for how the immune system generates an appropriate immune response to any perceived disturbance. On the the basis of this theory, the authors present a mathematical model and provide examples to explain how this model can account for diverse immune responses.