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This Review article outlines the evolution of non-surgical treatment for colorectal cancer, in particular chemotherapy, its integration with radiotherapy, and the evolving use of biologic therapies. The authors also discuss new advances in patient selection for specific anti-cancer agents and regimens.
A considerable proportion of patients with Crohn's disease are affected by the formation of fistulas, and appropriate fistula treatment requires knowledge of the available medical therapies. This Review discusses the pharmacological and surgical approaches available for the treatment of fistulas in patients with Crohn's disease, including novel therapeutic approaches. Discussion of the epidemiology and pathology of fistulizing Crohn's disease is also provided.
