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An experimental evolution study published in Science demonstrates that non-additive interactions between pollinators (bumblebees) and herbivores (caterpillars) drive rapid evolution in plants.
Two new spatial transcriptomics techniques published in Nature and Science bring us an important step closer to the goal of achieving transcriptome-wide data at single-cell resolution.
A fuller understanding of bacterial genomic variation could provide insight into host pathophysiology. A new study in Nature demonstrates that structural variants are highly prevalent in human gut microbiomes and that some associate with host disease risk factors.
A new study in Science reports the existence of a subpopulation of somatic cells from which ‘elite’ clones emerge that outperform other clones to drive reprogramming.
The clinical application of genomic technologies is driving new discoveries that may be relevant to individuals who have previously undergone genetic testing. This Comment highlights the need for a framework to decide whether to recontact patients and inform them of new genetic findings.
In a study in Nature Microbiology, Setoh et al. use deep mutational scanning to speed up viral evolution and identify key determinants of host tropism in Zika virus.
Two recent articles in Nature Reviews Genetics discuss the exciting opportunities of single-cell omics studies but also highlight the importance of appropriate data analysis strategies.
A study in Nature reveals that N6-methyladenosine (m6A) modification of RNA occurs co-transcriptionally and is mediated by interactions between histone H3 lysine 36 trimethylation (H3K36me3) and the m6A methyltransferase complex.
Nair et al. contrast events at specific super-enhancers after acute and chronic ligand-induced activation and show that biomolecular condensates at these enhancers undergo physical changes over time that affect chromatin conformation and gene expression.
A genomics-informed response to infectious disease has great potential to improve individual patient treatment as well as public health. This Comment discusses the ethical, legal and social challenges that will need to be overcome if clinical pathogen genomics is to be implemented successfully.
Variants of unknown significance (VUS) are genetic variants whose association with disease risk is unknown. The authors posit that VUS should not inform clinical decision-making as the benefits of returning this genetic information to patients undergoing genetic testing are outweighed by the potential for harm.
Two studies in Science show that cytosine base editors, but not adenine base editors or CRISPR–Cas9, induce notable off-target single-nucleotide variants in rice and in mouse embryos.
Chromosomal inversions that relocate a limb enhancer establish patterns of asymmetric chromatin contacts, so-called architectural stripes, that result in ectopic gene expression and congenital limb phenotypes, according to a study in Nature Cell Biology.
A new technique named ChIA-Drop combines chromatin interaction analysis (ChIA) with droplet-based and barcode-linked high-throughput sequencing to capture multiplex chromatin interactions at the single-molecule level.
A study published in Nature reports the functional and structural characterization of CasX, an RNA-guided DNA endonuclease with potential for use as a new genome editing platform.
A new study uses deep learning to predict genetic variants that generate cryptic splice sites and to investigate the role of these non-coding cryptic splice mutations in rare genetic disorders.
