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In this Perspectives article, the authors discuss the need for national policies to add ress the global problem of noncommunicable diseases. They present their views on the benefits of national policies and the processes involved in developing and implementing such policies.
Increases in the doses of ionizing radiation to Western populations have largely been driven by growth in the use of medical imaging tests, such as invasive coronary angiography and cardiovascular CT. Here, Dr. Einstein discusses the association between radiation dose and cancer risk, which has been the source of some controversy, and highlights the clinical implications of radiation exposure from imaging tests.
In this fascinating Perspective article, the authors propose a novel hypothesis for the developmental origin of the variable phenotypes seen in hypertrophic cardiomyopathy (HCM). They suggest that cross-talk between healthy epicardium-derived cells and abnormally contracting cardiomyocytes could account for the extramyocardial manifestations of HCM, by a putative mechanism of mechanotransduction leading to abnormal gene expression and cell differentiation.
