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Joseph Tabernero and colleagues have carried out a 'first-in-man' Phase I trial of two small interfering RNAs (siRNAs) to treat patients with refractory metastatic disease that involves the liver.
Two prospective studies reported inThe Lancet Oncologyhave shown that mRNA expression signatures from whole blood can be used to stratify patients with castration-resistant prostate cancer into high- and low-risk groups.