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The function of protein deacetylase SIRT1 in cancer is controversial: it has been shown to have oncogenic properties as well as tumour suppressor activity. How might these opposing functions be explained?
Which breast tumours does the term 'basal-like' best describe? In this Perspective the author argues that this term is misleading and explains why by use of current understanding of breast cancer pathology.
Tetraspanins have only recently received attention as both metastasis suppressors and metastasis promoters. The ability of these proteins to collect a variety of molecules associated with tumour progression or tumour suppression in membrane microdomains might explain their multifaceted functions in metastasis.
The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. This Perspective discusses how the function of the Toll-like receptors may relate to these processes in the context of carcinogenesis.