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Automated 3D design produces rapid and near-atomically accurate predictions of RNA tertiary structure as well as the ability to generate complex RNA machines such as functional single-stranded tethered ribosomes, and enhancement of the binding properties of small-molecule RNA aptamers.
Controlled delivery of neuromodulators in the brain might improve the understanding of the molecular basis of behaviour. In this letter, magnetic liposomes injected in deep brain regions release small molecules under remote magnetic stimulation, activating specific neuronal circuits in freely moving mice.
A repeated on–off high-temperature shockwave is shown to be a generalizable way of efficiently synthesizing and stabilizing single atoms at high temperatures.
Subject to force, molecules are more likely to move down a step defect than up the defect and are even more likely to be displaced along the step defect line.
Combination of dendritic-cell-targeted nanovaccines with a myeloid-derived suppressor cell inhibitor and immune checkpoint modulators expands the host antitumour immune cells, restricts tumour growth and prolongs survival in orthotopic melanoma models.
An in situ only fabrication process for networks of topological insulator–superconductor Josephson junctions with high interface transparency is introduced, which holds some potential for the production of future topological quantum computing networks.
In a ferromagnetic layer, an electric current parallel to the magnetization generates opposite spin–orbit torques on the two surfaces of the magnetic film, which is attributed to the generation of spin currents with a spin polarization transverse to the magnetization within the ferromagnet.
Random sequences of unitary gate operations on an exchange-only qubit encoded in three physical electron qubits are performed using only voltage pulses and exhibit an average total error of 0.35%, where half of the error originates from leakage out of the computational subspace caused by interactions with substrate nuclear spins.
Glutathione-mediated biotransformation in the liver sinusoids could modulate nanoparticle transport in vivo, which can be exploited to design nanoparticles with enhanced tumour targeting and reduced non-specific accumulation in the body.
An optoelectronic resistive switching memory synaptic device enables the realization of an efficient neuromorphic visual system exhibiting non-volatile optical resistive switching and light-tunable synaptic behaviours.
Nanopore AFM is used for the stochastic sensing of secreted molecules and the activity of ion channels in arbitrary locations both inside and outside a cell.
The spin state of electrons in a double quantum dot in silicon is read in a single shot with 98% average fidelity within 6 μs by means of an on-chip superconducting resonator connected to two of the gates defining the double dot structure.
The combination of two-photon lithography and high-temperature pyrolysis is used to create micro-sized pyrolytic carbon with a compressive strength of 9.79 GPa cm3 g−1. This enables rubber-like behaviour in micropillars, which can sustain compressive strain up to 50%.
Scalable ultrasmall U-shaped nanowire FET probe arrays enable recording of full amplitude intracellular action potentials from primary neurons and other electrogenic cells.
A zwitterionic camptothecin–polymer conjugate that is enzymatically transformed in a cationic molecule at the tumour periphery penetrates deep into tumours via caveolae-mediated endocytosis and transcytosis, resulting in high anticancer efficiency in vivo.