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Using genome-resolved metagenomics for 41 Arctic seawater samples, this ecogenomic analysis of 530 metagenome-assembled genomes (MAGs) from the polar Arctic Ocean reveals uncultured Arctic bacterial and archaeal MAGs, their gene expression patterns, habitat preferences and metabolic potential.
Analysis of the fungal and bacterial components of the intestinal microbiota of patients undergoing allogeneic haematopoietic cell transplantation identifies an association between fungal dysbiosis, an expansion of Candida parapsilosis complex species and worse patient outcomes.
Comparative RNA-seq, ChIP–seq and quantitative phosphoproteomics reveal how the blast fungus uses the Pmk1 MAP kinase to regulate a network of transcription factors that orchestrate the complex transcriptome changes necessary for infecting rice plants.
Analysis of the archaeal gut microbiota of 110 vertebrate species spanning five taxonomic classes revealed that host phylogeny could explain archaeal diversity.
Ancestral avian influenza A viruses are used to identify adaptive changes in viral polymerase and nucleoproteins that enable efficient replication and transmission in pigs.
Cryo-electron microscopy and cryo-electron tomography reveal conformational changes of the bluetongue virus capsid protein VP5 that lead to membrane perforation and virus release into the cytosol.
A genome-wide Tn-seq analysis of the rpoB H526Y mutant, a rifampicin-resistant Escherichia coli strain, identifies non-essential genes that modulate the fitness cost of mutations in the bacterial RNA polymerase that confer antibiotic resistance.
Algal production of dimethyl sulfide plays a role in attracting predators and enhancing predation by zooplankton, thus mediating predator–prey relationships in the ocean.
The marine bacterium Puniceibacterium antarcticum SM1211 can produce acrylate from dimethylsulfoniopropionate (DMSP) cleavage by the DMSP lyase, DddL, which protects against grazing by a ciliate predator.
Viral encephalitis caused in mice by La Crosse arbovirus can be treated with rottlerin, which prevents viral trafficking from the Golgi and reduces virus titres and neuronal cell death in the central nervous system.
Bifidobacterium species associated with breastfeeding can convert aromatic amino acids into their respective aromatic lactic acids via a previously uncharacterized aromatic lactate dehydrogenase, which may impact immune function in infants.
The authors assess the durability and long-term cross-reactivity of neutralizing antibodies raised in response to infections with SARS-CoV-2 or variants of concern in humans.
Quantification of gut bacterial strains after fecal microbiome transplantation using the Strainer algorithm delineates long-term stable engraftment that explains patient outcomes.
A prospective, cross-sectional survey of 12,572 participants in Ethiopia reveals that malaria diagnostics miss almost 10% of cases owing to a gene deletion in Plasmodium falciparum that is under positive selection.
Flies, insects and spiders can serve as vectors of multidrug-resistant Enterobacterales in a public hospital in Pakistan, according to a clinical and molecular epidemiology study.
Structural analysis of two human monoclonal antibodies that conform the antibody cocktail AZD7442, in complex with the RBD of SARS-CoV-2, reveal strong neutralization of SARS-CoV-2 variants of concern.
In this Article, the authors perform evolutionary analyses of M. abscessus clinical isolates and report the emergence of dominant circulating clones (DCCs) in non-cystic fibrosis (CF) individuals followed by amplification in the CF community.
Staphylococcus aureus pathogenicity islands are not all equal and can be satellites of pathogenicity islands or satellites of helper phages in a beguiling regulatory triad that enables pathogenicity island transfer.
In Bangladesh, genomics, social media and mobile phone data streams are integrated to map the spread of SARS-CoV-2 lineages and inform country-level policies to curb infection rates.