Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
As antibiotic-resistant infections continue to rise globally, the development and application of phage therapy represents not only a promising but also a mandatory alternative approach to tackle this major public-health threat.
Live tubeworm incubations reveal that chemoautotrophic symbionts regulate the Calvin–Benson–Bassham and reductive tricarboxylic acid pathways to suit geochemistry and metabolism.
Potent CRISPR guides targeting conserved dengue virus regions can treat dengue-2 and -3 infection in vivo in mice when co-delivered with Cas13 by lipid nanoparticles.
A real-world study of 100 diverse cases facilitated by a single centre for individualized bacteriophage therapy demonstrates feasibility and provides new hope for refractory and resistant bacterial infections.
Analysis of 100 consecutive personalized bacteriophage therapy cases supports the use of personalized and sometimes pre-adapted, bacteriophage preparations, often in combination with antibiotics.
Marine Group A isolate IA91 captures peptidoglycan fragments produced by other growing bacteria and uses them to build its own cell wall, an effective and potentially common energy-saving strategy for surviving in energy-limited ecosystems.
The vast stores of high-latitude peatland carbon are thought to be resistant to microbial degradation, but a multi-omics investigation suggests this might not be the case.
Diverse microbial polyphenol transformations in thawing permafrost refute the theory that these compounds stabilize soil carbon across Arctic landscapes.
Hypoxia induces d-serine production by Mycobacterium tuberculosis which inhibits mTORC1 and T-bet expression to restrict downstream CD8+ T cell immune responses and macrophage activation, and inhibit control of tuberculosis in mice.
Characterizing EBV and host gene expression profiles of spontaneous lymphoblastoid cell lines isolated from multiple sclerosis (MS) patients with acute or stable disease, as well as healthy donors, suggests antivirals as a potential road to treat MS.
Phylogenetic and functional analyses suggest that viral histones were acquired from early eukaryotes during eukaryogenesis and that nucleosome evolution proceeded through histone repeat intermediates.
Teresa O’Meara recounts her experience of approaching the emerging fungal pathogen, Candida auris, with an open mind, enabling her laboratory to uncover its unique biology.
Our study investigated microbial dynamics involved in the relative enrichment of oral bacteria in faeces. Results in mice and from human patients indicated that high percentages of oral bacteria reflect a depleted gut microbiota, with oral bacteria simply passing through rather than expanding in the gut, which has implications for gastrointestinal disease treatment.
Interactions between Peptostreptococcus anaerobius and host cells promote recruitment and activation of myeloid-derived suppressor cells, leading to anti-PD1 immune checkpoint inhibitor resistance and exacerbated colorectal cancer in mice.