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β-barrel outer-membrane proteins are covalently attached to peptidoglycan in Gram-negative bacteria including Coxiella burnetii, Agrobacterium tumefaciens and Legionella pneumophila.
Bacterial–fungal interactions are studied using a combination of random barcode transposon-site sequencing, RNA sequencing, bacterial cytological profiling and metabolomics. Fungi cause widespread changes in the fitness of bacterial mutants and have both conserved and species-specific impacts on bacteria.
In α-proteobacteria, such as Brucella and Agrobacterium, the outer membrane is attached to the peptidoglycan by covalent cross-links between β-barrel-shaped proteins and peptidoglycan.
Here, the authors show that Salmonella activates the cytosolic PRR Nod-like Receptor CARD 4 (NLRC4), which limits adaptive T-cell responses in a NLRP3-dependent manner. Modification of Salmonella flagellin reduces NLRC4 activation and enhances protective immunity.
A longitudinal genomic surveillance of Enterococcus faecium carriage, environmental contamination and transmission in a defined patient cohort shows that a hospital-adapted E. faecium lineage was hyperendemic.
Neutralizing antibody responses of patients infected with SARS-CoV-2 peak at 3–4 weeks post onset of symptoms, then decline to low levels over the course of 3 months in some individuals.
Do you ‘beat’ or ‘treat’ a virus infection? Are you strong if you survive SARS-CoV-2 but weak if you don’t? Language matters if we are to galvanize people to follow public health guidance during the COVID-19 pandemic.
Sub-inhibitory levels of an antibiotic switch on cryptic stress pathways in Escherichia coli that result in the production of immunomodulatory molecules.
Summer research programmes are renowned for encouraging underrepresented minorities (URMs) to pursue STEM careers, but COVID-19 left many students in the United States unable to participate. We created the National Summer Undergraduate Research Project to matchmake students with mentors, enabling 250 URM students to do summer research.
Drug used to treat Helicobacter pylori infection reduces SARS-CoV-2 viral loads in lungs and alleviates virus-associated pneumonia in a golden Syrian hamster model.
Glycolytic Staphylococcus aureus generate lactate that targets specific histone deacetylases to stimulate the production of IL-10 and enable biofilm formation.
Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.