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Multiwell plates used for the creation of tagged mammalian transgenes. Cover design by Erin Boyle, inspired by M.C. Escher's artwork. Article p409, News and Views p383
A high-throughput pipeline to engineer bacterial artificial chromosomes (BACs) expressing tagged genes of higher eukaryotes allows large-scale protein localization and interaction studies.
A spheroid assay that recapitulates angiogenesis in vivo and a ring assay to measure lymphangiogenesis in vitro expand the toolbox of techniques to investigate these processes during development and tumor progression.
Microscopic resolution far beyond the diffraction limit is possible by localizing single molecules individually. This approach has now been demonstrated on living cells.
With abundant sequencing data, falling prices and mature genotyping platforms, researchers have more options than ever to explore the connections between genes and phenotype.