Volume 5

  • No. 12 December 2008

    A probabilistic map of the locations of several genomic loci within the yeast nucleus, overlaid onto fluorescence images of yeast, from which such maps can be derived. Cover design by Erin Boyle, based on images provided by Christophe Zimmer. Aricle p1031

  • No. 11 November 2008

    Congratulations to the winner! This photograph of marine diatoms Pleurosigma sp. took first place in the 2008 Nikon Small World photomicrography competition. The image was taken using darkfield and polarized light by Michael Stringer of Westcliff-on-Sea, Essex, UK. Other images from this year's competition are on display at http://www.nikonsmallworld.com/.

  • No. 10 October 2008

    Protein structural dynamics can be monitored with nanosecond time resolution by using the synchrotron-based technique of time-resolved wide-angle X-ray scattering (TR-WAXS). Artistic interpretation by Erin Boyle. Article p881

  • No. 9 September 2008

    An artistic interpretation of bacterial conjugation used to generate double mutants. Cover design by Erin Boyle. Articles p781, p789, News and Views p759

  • No. 8 August 2008

    Inverted fluorescence microscopy images of cells showing membrane receptors labeled with quantum dots overlaid with simulated singleparticle trajectories. Cover design by Erin Boyle using images supplied by Didier Marguet and Khuloud Jaqaman. Articles p687, p695, News and Views p671

  • No. 7 July 2008

    RNA-Seq, direct 'nextgeneration' sequencing of cDNA, can reveal alternative splice forms, as shown for the mouse Vegfb gene. Sequencing data, as they appear on the University of California, Santa Cruz genome browser, were generated by the group of Barbara Wold as part of their extensive survey of mouse transcriptomes beginning on page 621. Cover design by Erin Boyle. Articles p613, p621, News and Views p585

  • No. 6 June 2008

    Artist's rendition of isoSTED microscopy based on an idea by Roman Schmidt, Alexander Egner and Stefan Hell. The opposing objectives and resulting spherical imaging spot used in isoSTED microscopy are shown beside a vertical stack of isoSTED images of Tom20 protein in a mitochondrion after immunofluorescence labeling. Cover by Erin Boyle. Article, p539, News and Views p471

    Focus

    Focus on Single-Molecule Analysis

  • No. 5 May 2008

    Multiwell plates used for the creation of tagged mammalian transgenes. Cover design by Erin Boyle, inspired by M.C. Escher's artwork. Article p409, News and Views p383

  • No. 4 April 2008

    Artistic representation of the alteration of neuronal excitability after photo-affinity labeling and exposure to different wavelengths of light. Cover by Erin Boyle. Article p331, Brief Communication p299, News and Views p293

  • No. 3 March 2008

    Holstein cow with a calf. Image from iStockphoto and adapted by Erin Boyle. Article, p247

  • No. 2 February 2008

    Structural genomics refers to the high-throughput effort of rapidly solving three-dimensional protein structures. Cover by Erin Boyle, using a selection of images of protein structures solved by various structural genomics consortia: the SGC, JCSG, NYSGXRC, RIKEN, OPPG, ISFI and AFMB. Commentary p129, Review p135, Perspective p147, Technology Feature p203