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Neuroscience methods are undergoing a dramatic change owing to improvements in optical probes, but standardized evaluation procedures would aid probe development and uptake.
Two methods enable the drawing of genome-wide chromatin interaction maps: one looks at protein-independent folding principles, the other at protein-mediated functional interactions.
They are the quintessential drug target—but the dynamic structures and highly elaborate mechanisms of G protein–coupled receptors continue to keep experts in both industry and academia on their toes.
Certain yeast previously assumed to lack RNA interference machinery instead have alternative enzyme variants, which can in turn be transplanted to truly deficient species.