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This study shows the importance of proper metrics for comparing algorithms for bioimage segmentation and object detection by exploring the impact of metrics on the relative performance of algorithms in three image analysis competitions.
Open-3DSIM is a versatile open-source software for high-fidelity reconstruction of three-dimensional structured illumination microscopy data (with polarization). It is available in three convenient forms for user-friendly and customizable applications.
This study shows, when analyzing multi-sample metagenomic datasets, the multi-coverage binning approach outperforms the single-coverage binning alternative in generating bins with higher quality and less contamination.
Expansion spatial transcriptomics (Ex-ST) combines the power of tissue expansion with an improved RNA capture protocol for carrying out capture array-based spatial transcriptomics at high spatial resolution.
This paper proposes two new anisotropy metrics—the Fourier shell occupancy and the Bingham test—that can be used to understand the quality of cryogenic electron microscopy maps.
For EM-based connectomics applications, a staining protocol for large tissue samples in the range of a centimeter has been developed, which avoids artifacts common with established protocols.
Crowdsourcing condensate database and encyclopedia is a community-editable platform for verified biomolecular condensates and their protein constituents. It also provides an encyclopedia for the scientific terms used in condensate biology and a crowdsourcing web application.
Two mScarlet variants with high brightness and fast maturation times have been evolved. These variants behave favorably as fusion tags and Förster resonance energy transfer acceptors.
A modular architecture for managing and sharing electrophysiology, behavior, colony management and other data has been built to support individual laboratories or large consortia.
Outbreak.info Research Library collects and integrates COVID-19 information from various repositories, enabling one-stop search for publications, clinical trials, datasets and other resources.
EnzymeML is an XML-based markup language that enables FAIR (findable, accessible, interoperable and reusable) storage and exchange of enzymatic data such as reaction conditions, the time course of the substrate and the product, kinetic parameters and the kinetic model.
LILAC is a photoactivatable version of Lifeact, a tool for labeling F-actin. LILAC can help avoid cytotoxicity, which is sometimes associated with the use of Lifeact.
Antibody-barcode eCLIP (ABC) uses proximity ligation to couple DNA-barcoded antibodies to RNA-binding protein (RBP)-protected RNA fragments for multiplexed eCLIP. ABC can be used to interrogate several RBPs in a single tube with results on par with eCLIP.
miRFP718nano is a rationally designed small near-infrared fluorescent protein with an emission tail that extends into the short-wave infrared range for improved multiplexed and deep-tissue imaging applications.