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In the observational GALAXY arm of the CIRCULATE-Japan study, among 1,049 patients with stage II–IV colorectal cancer, those with presence of circulating tumor DNA (ctDNA) after tumor resection have a high recurrence risk and are likely to benefit from adjuvant chemotherapy.
Comparison of non-invasive [11C]metomidate PET-CT with adrenal vein sampling for predicting biochemical remission of primary aldosteronism showed non-superiority, suggesting that the non-invasive method is suitable for the diagnosis of unilateral primary aldosteronism.
With the lifting of the zero-COVID policy and requirements governing reporting case numbers in China, it has become imperative to estimate the dynamics and cumulative infection rate of SARS-CoV-2 to help guide public health responses.
In a randomized, crossover trial in adults with type 2 diabetes, fully closed-loop insulin delivery increased time in target glucose range compared with standard insulin therapy, without increasing hypoglycemia.
In the third annual iteration of a survey assessing vaccine confidence in 23 high-income, middle-income and low-income countries, although results were heteregeous across countries, overall willingness to accept a COVID-19 vaccine was found to have increased.
A deep learning model trained on multiple tumor immune cell stainings from patients with colorectal cancer outperforms currently used clinical and single tumor immune cell staining-based parameters in predicting prognosis. The model can also predict the response to neoadjuvant therapy.
Integrative genomic and transcriptomic analyses reveal molecular events defining Richter transformation from CLL, and highlight the potential of cell-free DNA for early detection.
Phase 1 trial results reveal that intrathecal transplantation of human fetal neural precursor cells in patients with progressive multiple sclerosis is feasible, safe and tolerable.
In a phase 1 dose-escalation trial in patients with nine different types of solid tumors, MAGE-A4-specific T cells had an acceptable safety profile and exhibited an encouraging overall response rate in patients with synovial sarcoma.
Pharmacotyping analyses of large cohorts of pediatric acute lymphoblastic leukemia identify correlations between drug sensitivities and clinical outcomes across different genomic subtypes.
Analysis of peripheral mycobacteria-reactive CD4+ T cell receptor sequences from individuals infected with Mycobacteriumtuberculosis shows a high degree of overlap between progressors and controllers, but points to some distinct clonotypes that are enriched in either group.
Analysis of data from California prisons shows that both COVID-19 vaccination and prior SARS-CoV-2 infection reduces the risk of virus transmission to close contacts.