News & Comment

In patients with resected, high-risk melanoma, the addition of a personalized mRNA-based neoantigen therapy to adjuvant pembrolizumab was more effective than pembrolizumab alone.

Implementation of multifactorial interventions in a low- to middle-income setting during preconception, pregnancy and early childhood resulted in improvements to child neurodevelopment at 24 months of age.

Researchers used machine-learning models to emulate thousands of clinical trials from over 10 years’ worth of real-world data, generating a shortlist of five candidate drugs for repurposing.

Known as tethered macrocyclic peptides, a new class of antibiotics show potent activity against drug-resistant strains of Acinetobacter baumannii — with one candidate already in clinical trials.

Two recent papers illustrate that a noninvasive technique can be used for extensive prenatal genetic screening — potentially enabling earlier diagnosis of many conditions.

A focus on maternal mortality reduction and time-restricted follow-ups after childbirth has led to neglect of long-term labor and birth complications experienced by women.

In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide significantly reduced the risk of major cardiovascular events.

The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and locations in the USA, which underscores the inequities in its real-world implementation.

The report — the first of its kind from the WHO — is intended as a roadmap for building responsive and inclusive health systems for displaced people.

A citizen science approach has helped craft a resource-rich vaginal microbiome map with associations to lifestyle and events across a woman’s life course.

A quadrivalent vaccine against human papillomavirus produced by the Serum Institute of India was shown to be noninferior to the established quadrivalent vaccine — boosting global efforts to eliminate cervical cancer.

A machine-learning diagnosis tool, based on low-cost sequencing, can assist decision-making during brain surgeries.

A study has found that people with intermediate levels of scientific knowledge have the highest levels of overconfidence — and the most negative attitudes toward science.

Using an array of multi-omic and other technologies, scientists have comprehensively mapped the types and specialties of brain cells — revealing insights into human evolution, development and disease.

Brain insulin action, previously well studied in men, is now shown to improve peripheral insulin sensitivity during the follicular phase but not the luteal phase of the menstrual cycle.

First-line treatment with dabrafenib plus trametinib resulted in better clinical responses and lower toxicity than chemotherapy in children with BRAF V600E mutation and low-grade glioma.

As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.

Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to day 14, opening new avenues of research into early human development.

Produce prescriptions improved fruit and vegetable intake, reduced food insecurity and improved biomarkers of cardiometabolic health, according to a large, retrospective, US-based study.

A monumental challenge to scientists due to its repetitive sequences, the human Y chromosome has now been fully sequenced — revealing new structures in regions critical for fertility.