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    Chronic pain is estimated to affect over one-quarter of the world's population, and presents a considerable therapeutic challenge. This Nature Collection brings together articles from Nature,Nature Medicine,Nature Neuroscience,Nature Reviews NeurologyandNature Reviews Neurosciencethat highlight recent advances towards understanding the risk factors and mechanisms that underlie chronic pain, and developing effective, non-addictive treatments for this highly prevalent condition.

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    Gene silencing through RNA interference (RNAi) has become the tool of choice for genome-scale, high-throughput analyses of gene function and has had a tremendous impact on science and drug discovery. Now, RNAi libraries targeting whole genomes or functionally related pathways permit systematic screens for clinically relevant components of cellular networks. Advances in rational design, sequence selection strategies and delivery options have substantially improved the utility of short interfering RNA (siRNA), short hairpin RNA (shRNA) and microRNA (miRNA) tools for screening.

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    Welcome to the content sampler of Nature Medicine. Since 1995, our journal has been at the forefront of publishing translational medicine, way before the term was even coined. Our focus on publishing basic and preclinical work that has direct relevance to human disease has been a key characteristic of Nature Medicine that has helped establish the reputation of the journal in the translational research landscape.To put together this sampler, we have chosen a series of recent articles from our pages, organized them by therapeutic area, and made them freely available in order to give you a glimpse of the breadth of Nature Medicine's coverage, as well as the quality of the science we publish.In addition, we have chosen a few landmark articles that we had the privilege to publish over the past 15 years in an effort to illustrate why Nature Medicine is the "Home of Translational Research".

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    A joint web focus and print supplement between Nature Medicine and Nature Cell Biology.