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Volume 3 Issue 9, September 2002

B cells diversify the repertoire of antibodies by increasing the rate of mutation in the region of the gene that codes for the antigen-binding site. Reynaud and colleagues (page 815, with News and Views by Honjo, page 802) report that the BL2 Burkitt's lymphoma B cell line (purple-blue shapes) can be used to quickly characterize this process of somatic hypermutation, in an inducible, AID-dependent fashion. Artwork by Mark Sokoloff.

Volume 3 Issue 9

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Editorial

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Correspondence

    • Robert I. Lechler
    • Megan Sykes
    • Laurence A. Turka
    Correspondence
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Commentary

  • Historical insight: The clonal selection theory of antibody formation has recently been subjected to challenge from many quarters. A review of its history and that of scientific theories in general points to the importance of distinguishing between the central hypotheses of a theory and its subsidiary implications.

    • Arthur M. Silverstein
    Commentary
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News & Views

  • The existence of two distinct lineages of TH1 cells may explain the relationship between activated effector TH1 cells and long-term TH1 memory cells.

    • Hans Dooms
    • Abul K. Abbas
    News & Views

  • T cell help is not obligatory for B cell Ig class switching. Instead, DC expression of BLyS and APRIL can provide the signals to induce T-independent B cell production of IgG and IgA.

    • Andrew J. Macpherson
    • Alain Lamarre
    News & Views

  • AID burst onto the scene just a couple of years ago. For all of the progress, its actual mechanism for generating changes in DNA in B cells remains elusive.

    • Tasuku Honjo
    News & Views

  • NF-κB is important in many biological processes and is activated by ubiquitous protein kinases. However, in T cells, its activation is regulated by a specific set of adapter proteins.

    • David Wallach
    News & Views

  • “Cross-presentation” can prime CD8+ T cells. A transplantation system now reveals its role in destruction of the host endothelial cells that feed the graft.

    • Herman Waldmann
    News & Views
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Round-up

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Review Article

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Article

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