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Volume 3 Issue 5, May 2002

Terminal deoxynucleotidyl transferase, or TdT, inserts additional nucleotides to immunoglobulin and T cell antigen receptor genes. Kearney and colleagues report on page 457 that the short and the long forms of this enzyme have distinct activities, with the former acting as a DNA polymerase and the latter as an exonuclease.

Volume 3 Issue 5

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Editorial

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Correspondence

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Commentary

  • Immunologists gather at Asilomar each January in a pleasant and informal setting to discuss recent findings on the development and regulation of immune responses.

    • Jonathan Sprent
    • Christel H. Uittenbogaart
    • Pamela J. Fink
    Commentary
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News & Views

  • Synapse formation in the immune system and the nervous system have common features. The identification of neuropilin-1, a neuronal receptor, as participating in naïve T cell–DC contact helps emphasize the molecular similarities between these systems.

    • Christoph Wülfing
    • Fabio Rupp
    News & Views

  • The pTα cytoplasmic chain was initially thought to be dispensable for T cell development. A reanalysis of the pTα cytoplasmic tail now shows this domain plays a critical role in pre-TCR signaling.

    • Nigel Killeen
    News & Views

  • CD1 presents lipid antigens to T cells. Intrinsic properties of microbial lipids, such as alkyl chain length, may be essential determinants of their efficient presentation to T cells.

    • Albert Bendelac
    • Luc Teyton
    • Paul B. Savage
    News & Views

  • In some autoimmune diseases, antibodies form that recognize other self-antibodies or DNA. A recent report in Nature implicates the Toll-like receptor 9 and innate immunity as a possible key to understanding the initiation of this process.

    • Arthur M. Krieg
    News & Views
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