Volume 3 Issue 4, April 2002

Artist's rendition of the tell-tale "cobble-stone" colonies formed by hematopoietic stem cells (HSCs) in culture. The radial design suggests the various blood lineages spun from the central pluripotent stem cells. Five solicited commentaries and reviews in this issue of Nature Immunology are devoted to HSCs, including the controversies, progress and potential of these amazing (and vital) cells. Our Focus on HSCs website (http://immunol.nature.com) is free to registrants, will be updated regularly and contains additional features of interest to those curious about HSCs.

Editorial

Betting on HSCs

Editorial 01 Apr 2002

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Round-up

Immunology highlights from the recent literature

Round-up 01 Apr 2002

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Commentary

Multilineage development from adult bone marrow cells

The potential of hematopoietic stem cells to generate tissue-specific lineages varies with the criteria used to isolate such cells. New discoveries continue to refine our definition of what a hematopoietic stem cell is and what it can do.

Kenneth Dorshkind
Commentary 01 Apr 2002
Hematopoietic stem cells for transplantation

Multiple sources of HSCs exist. Here, Verfaillie discusses the long-term engraftment capabilities of each source and the search for ex vivo expansion conditions to allow bulk culture for therapeutic HSC transplantation.

Catherine M. Verfaillie
Commentary 01 Apr 2002
Therapeutic applications for hematopoietic stem cell gene transfer

Transfer of genes into HSCs could be used to treat a variety of diseases from AIDS to cancer. Here Bordignon and Roncarolo discuss the logistics and progress of HSC gene transfer technology for the treatment of different diseases.

Claudio Bordignon
Maria Grazia Roncarolo
Commentary 01 Apr 2002

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Review Article

Hematopoiesis and stem cells: plasticity versus developmental heterogeneity

Stuart H. Orkin
Leonard I. Zon
Review Article 01 Apr 2002
The aging of lympho-hematopoietic stem cells

Hartmut Geiger
Gary Van Zant
Review Article 01 Apr 2002

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Correspondence

Cellular environment and freedom of gene expression

Massimo Pietropaolo
Nick Giannoukakis
Massimo Trucco
Correspondence 01 Apr 2002
Lymphoid organs contain diverse cells expressing self-molecules

Alberto Pugliese
Juan Diez
Correspondence 01 Apr 2002
Response to 'Lymphoid organs contain diverse cells expressing self-molecules'

Bruno Kyewski
Jens Derbinski
Ludger Klein
Correspondence 01 Apr 2002

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News & Views

Killed by leukocytes that don't know when to leave

Patients with severe asthma accumulate inflammatory cells in their airway walls. Studies with MMP2-deficient mice now show that an inability of these cells to egress from the lung can be fatal.

Dean Sheppard
News & Views 01 Apr 2002
Type 1 diabetes: virus infection or autoimmune disease?

What does Coxsackie virus have to do with diabetes? Evidence is emerging that insulin-producing β cells are highly susceptible to acute infection by Coxsackie virus if their production of interferon is inhibited, resulting in diabetes.

DeLisa Fairweather
Noel R. Rose
News & Views 01 Apr 2002
Microbial killing: hold the bleach and pass the salt!

The current paradigm is that reactive oxygen species produced by leukocytes directly kill bacteria. Data in a recent Nature article belie that simplicity.

Gary M. Bokoch
News & Views 01 Apr 2002
Revival of the autoantibody model in rheumatoid arthritis

Toshio Hirano
News & Views 01 Apr 2002
Class II peptide multimers: promise for type 1A diabetes?

Lack of proper tools hampers early diagnosis and treatment of antigen-specific autoimmune diseases. A new strategy that makes use of peptide-MHC reagents could control recent-onset diabetes in mice.

George S. Eisenbarth
Gerald T. Nepom
News & Views 01 Apr 2002

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Round-up

Immunology highlights from the recent literature

Round-up 01 Apr 2002

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Article

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

David B. Corry
Kirtee Rishi
Farrah Kheradmand
Article 11 Mar 2002
Human Toll-like receptor 4 recognizes host-specific LPS modifications

Adeline M. Hajjar
Robert K. Ernst
Samuel I. Miller
Article 25 Mar 2002
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

Isao Matsumoto
Mariana Maccioni
Christophe Benoist
Article 18 Mar 2002
Dynamic visualization of a joint-specific autoimmune response through positron emission tomography

Brian T. Wipke
Zheng Wang
Paul M. Allen
Article 18 Mar 2002
Target cell defense prevents the development of diabetes after viral infection

Malin Flodström
Amy Maday
Nora Sarvetnick
Article 04 Mar 2002
Down-regulation of diabetogenic CD4⁺ T cells by a soluble dimeric peptide–MHC class II chimera

Sofia Casares
Alicia Hurtado
Teodor-Doru Brumeanu
Article 25 Feb 2002
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

Vladimir Toshchakov
Bryan W. Jones
Stefanie N. Vogel
Article 18 Mar 2002
Role of antigen receptor affinity in T cell–independent antibody responses in vivo

Tien-An Yang Shih
Mario Roederer
Michel C. Nussenzweig
Article 18 Mar 2002

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Correction

Correction: Development of chronic colitis is dependent on the cytokine MIF

Ype P. de Jong
Correction 01 Apr 2002

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Focus

Hematopoietic Stem Cells

The hematopoietic stem cells that reside in our bone marrow might aptly be described as our source of vitality. This focus contains an analysis of progress and news in hematopoietic stem cell research.

Focus 01 Apr 2002

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Volume 3 Issue 4, April 2002

Editorial

Betting on HSCs

Round-up

Immunology highlights from the recent literature

Commentary

Multilineage development from adult bone marrow cells

Hematopoietic stem cells for transplantation

Therapeutic applications for hematopoietic stem cell gene transfer

Review Article

Hematopoiesis and stem cells: plasticity versus developmental heterogeneity

The aging of lympho-hematopoietic stem cells

Correspondence

Cellular environment and freedom of gene expression

Lymphoid organs contain diverse cells expressing self-molecules

Response to 'Lymphoid organs contain diverse cells expressing self-molecules'

News & Views

Killed by leukocytes that don't know when to leave

Type 1 diabetes: virus infection or autoimmune disease?

Microbial killing: hold the bleach and pass the salt!

Revival of the autoantibody model in rheumatoid arthritis

Class II peptide multimers: promise for type 1A diabetes?

Round-up

Immunology highlights from the recent literature

Article

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

Human Toll-like receptor 4 recognizes host-specific LPS modifications

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

Dynamic visualization of a joint-specific autoimmune response through positron emission tomography

Target cell defense prevents the development of diabetes after viral infection

Down-regulation of diabetogenic CD4⁺ T cells by a soluble dimeric peptide–MHC class II chimera

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

Role of antigen receptor affinity in T cell–independent antibody responses in vivo

Correction

Correction: Development of chronic colitis is dependent on the cytokine MIF

Focus

Hematopoietic Stem Cells

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