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The recent demonstration that T cells can recognize a single foreign pMHC complex suggests that TCR triggering does not require aggregation. Or does it?
South Africa is in the throes of an AIDS epidemic compounded by tuberculosis. Nevertheless, responses to the recent launch of a colorful book promoting adolescent knowledge of HIV immunopathogenesis provide grounds for cautious optimism that education can induce a form of “social vaccination” in South Africa and elsewhere.
Proteolytic cleavage generates the peptide repertoire displayed by MHC class I. Now, an interferon-γ–inducible aminopeptidase in the endoplasmic reticulum has been identified as the final player in this complex process.
Receptors in the immune system usually specialize in transmitting specific types of signals. However, by associating with two different signaling subunits, the receptor NKG2D can transmit distinct signals for either costimulation or full-fledged activation.
The source of Langerhans cells is controversial. New data show that the repopulation of these cells depends on how and to what extent, they are depleted from the skin.