Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Karpf et al. showed that distinct layers of the adult human and mouse DG are populated by astrocytes, which exhibit a subtype-specific molecular profile and morphology, leading to subtype-specific physiological characteristics.
Using dual-color mesoscopic imaging in the neocortex of awake mice, the authors show that cholinergic release and neuronal activity exhibit distinct spatiotemporal patterns that are differentially linked to spontaneous fluctuations in behavioral state.
Cichon et al. show that ketamine induces a switch in the active population of excitatory neurons across cortical layers and regions that contributes to impairments in sensory processing characteristic of a dissociative-like state.
Zambusi, Novoselc et al. show that granulin-mediated clearance of cytoplasmic TDP-43+ condensates and lipid droplets in injury-activated microglia is required for their return to the homeostatic state and successful brain regeneration.
Chiou et al. provide a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques.
Zhu et al. develop a deep learning method to precisely infer single-trial neural dynamics from calcium imaging with subframe temporal resolution, which shows improvement over the state-of-the-art methods in capturing high-frequency dynamics and predicting behavior.
Liu and colleagues show that REM sleep in mice can be divided into two distinct substages and that the RSC dictates global cortical dynamics during sleep and plays a role in regulating transitions between REM sleep substages.
Motor planning can improve performance but can also lead to premature actions. The authors show that the anterior lateral motor cortex plays an important role in impulsive behavior by encoding and influencing premature motor output.
Using chronic neural recordings, the authors show that long-term stability in both skilled and natural behaviors is associated with stable single neuron activity patterns in relevant motor circuits.
Martinez et al. identified the protein interactome of the tau seed responsible for propagation. The authors found how the presynaptic protein Bassoon interacts with the tau seed enhancing its stability and subsequently tau toxicity and spreading.
In this work, the authors transcriptionally and genetically profile 443 caudate nucleus samples, including 154 with schizophrenia, highlighting new genes associated with schizophrenia risk, including the presynaptic DRD2 isoform.
Using new phagocytosis reporter mice and 3D ultrastructural characterization, Morizawa et al. show that motor learning induces synaptic engulfment by BG, which contributes to synaptic pruning during the improvement of motor adaptation.
Oh et al. modeled age-dependent onset of Huntington’s disease by comparing reprogrammed neurons from pre-symptomatic and symptomatic patients. They found that an age-associated miRNA led to autophagy impairment and neurodegeneration.
Leng et al. establish CRISPRi screens in astrocytes to dissect pathways controlling inflammatory reactivity. They uncover two distinct inflammatory reactive signatures that are inversely regulated by STAT3 and validate that these exist in human disease.
Hansen et al. compile and share an atlas of neurotransmitter receptor/transporter densities in the human cortex and show that receptor achitecture reflects brain structure, function, dynamics, cognitive specialization and disease vulnerability.
Somatosensory neurons detect pain, temperature and touch. Keeler et al. constructed a single-cell, protein-level atlas of nearly 3 million cells from the mouse dorsal root ganglia, covering 13 days of embryonic and postnatal development.
Aging is associated with the formation of focal white matter lesions and atrophy. The authors discovered a role for CD8+ T cells in driving white matter-specific interferon responses in microglia and oligodendrocytes, leading to oligodendrocyte loss.
Scheggia and colleagues present a social decision-making assay in which mice display altruistic or selfish choices. The authors show that projections between the prefrontal cortex and the basolateral amygdala are involved in the control of the two different choices.
Furlan et al. report that neurotensin-expressing neurons in the IPAC encode preference for unhealthy energy-dense foods and drive hedonic eating. Thus, inhibition of these neurons reduces hedonic eating, improves metabolic health and prevents obesity.