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Invariant natural killer T (iNKT) cells are important contributors to anti-tumour immunity, but they often become dysfunctional in cancers. Here authors show that inhibited iNKT intra-tumour motility and iNKT cell exclusion from tumours by macrophages both contribute to their diminished function in cancer, and by therapeutic interference with the respective motility and iNKT-macrophage interaction pathways, their function can be restored.
Abrupt millennial-scale climate variability, known as Dansgaard-Oeschger (D-O) events, characterized the last glacial. Stalagmite data from northern Türkiye show D-O events for the penultimate glacial period, though they were less frequent.
Measles virus infection causes immunosuppression and it’s unclear whether this can be prevented by antivirals. Here, using a canine distemper virus ferret model, the authors show that measles-like immune amnesia and lethal exacerbated respiratory disease after consecutive respiratory virus infections can be mitigated by oral antiviral therapy initiated at the onset of primary clinical signs.
Soil priming could release large amounts of soil C into the atmosphere. Here the authors show that experimental warming boosts soil priming and CO2 emissions in grasslands potentially due to microbial changes. Model accuracy could be improved by incorporating these mechanisms.
Here, the authors utilise an integrative approach to characterise the fuzzy heterocomplex between CXCL12 and the fully reduced alarmin HMGB1, highlighting the importance of HMGB1’s acidic IDR to the interaction and with cell surface CXCR4.
Characterising the tumour microenvironment features of lung adenocarcinoma (LUAD) remains crucial. Here, the authors perform single cell RNA sequencing data analysis of 117 LUAD samples and functional assays and highlight the immunosuppressive role of UPP1high tumour cells.
Many MOFs feature carboxylate ligands with strong coordination bonds, hindering thermal melting. Here, authors present a meltable carboxylate MOF designed with a thermodynamically favored component.
There is a need for effective antiviral drugs against RSV infection. Conducting an RSV repurposing screen using the ReFRAME library Sake et al. identify lonafarnib as an RSV fusion protein inhibitor, characterize its binding site within the viral protein and show its antiviral effects in a mouse model.
Glucocorticoids, potent anti-inflammatory drugs, can cause or exacerbate obesity, yet the underlying molecular mechanisms remain largely unknown. Here, the authors show KLF9 in macrophages integrates the beneficial anti-inflammatory and adverse metabolic effects of glucocorticoids.
The authors make an ionic thermoelectric cell with a eutectic solvent of formamide that can operate at temperatures as low as −35 °C by applying hydrophilic and gold coated treatments to the electrode and introducing a thermal separator.
THOC2 is an essential subunit of Transcription mRNA Export complex of eukaryotic cells and its compromise causes adverse (neuro)development. Using mouse model and patient cells the authors unravel molecular pathology of the syndrome, from R-loops dysregulation, to altered transcriptome and DNA damage triggered cell death.
Neonatal brain dynamics are not well understood. Here, the authors characterise brain transient states in neonates, and show that preterm infants display altered whole brain dynamics and an atypical repertoire of regional transient states, which are associated with behavioural outcomes at 18 months of age.
Detecting hydrogen gas in humid air is an unresolved challenge of significant importance for the safe implementation of hydrogen (energy) technologies. Here, authors demonstrate how the use of neural networks enables the sensing of hydrogen in highly humid air with a detection limit of 100 ppm.
Due to recent fluctuations in lithium prices, the instability of lithium-ion batteries prices is on the rise. Here, through a re-evaluation of purity criteria, the authors report that the presence of magnesium impurity in lithium precursor actually improves cathode performance, economics, and environmental aspects.
In this work, authors propose a synergistic approach combining state-of-the-art deterministic forecasting model with artificial intelligence for predicting lightning occurrences. The strategy shows efficient predictive capabilities at medium-range forecast horizons.
Overfeeding triggers a mechanistically ill-defined compensatory response that counteracts weight gain. Here, the authors show that the defence against overfeeding is preserved in obesity, and that it is independent from FGF21 and MC4R.
Low thermal conduction and conformability of traditional rigid heat sinks limit their adoption in flexible electronics and soft robotics. Here, authors report a liquid metal skeleton-based active-cooling elastomer with high thermal conductivity, stretchability, and hydraulic-driven adaptable morphing.
Children produce drawings prolifically throughout childhood. Here, the authors conducted a systematic study of how children create and recognize line drawings across development and suggest that changes in children’s drawings reflect refinements in how children represent visual concepts.
Micro-sized silicon are promising anode materials due to low-cost and high-energy, yet their application is hindered by inaccessible electrolytes. Here, the authors report sulfolane-based electrolytes that form silicon-phobic interphases and enable high-voltage pouch cells to achieve superior cycle life.
Post-stroke walking impairment is a significant public health concern. Here, the authors perform an interventional, randomized controlled trial evaluating the efficacy and safety of InTandem™, an autonomous neurorehabilitation system utilizing auditory-motor entrainment to improve walking after stroke.