Articles

KtrAB complex is essential in K⁺ uptake for bacteria. Here authors illustrate the synergism of ATP and Na⁺ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na⁺-activated K⁺ channels.

Primaquine treatment for breastfeeding mothers is currently not recommended. Here, the authors develop a pharmacokinetic model to predict drug exposure of infants and show that ingesting breastmilk from mothers treated with primaquine results in <1% of maternal drug exposure. This suggests that primaquine should not be restricted in post-neonatal breastfeeding women as standard doses are unlikely to cause adverse events in infants.

The authors study a YbCoIn5/CeCoIn5/YbRhIn5 heterostructure. Using non-reciprocity in the second harmonic transport response, they demonstrate the existence of a specific form of finite-momentum pairing called a helical superconducting state, where the phase of the order parameter is spontaneously spatially modulated.

As quantum simulations advance, the ability to measure response functions of simulated systems becomes increasingly important. Here the authors present a linear response framework for computing fermionic and bosonic response functions on a quantum computer, demonstrating advantages over existing methods.

Engineering of a biosensor allows the authors to map the signaling activity of the phytohormones gibberellins (GAs) and to show that GAs orient cell division at the shoot apex to establish the organization in parallel cell files of plant stems.

So far, only homoleptic N₂ complexes of silicon have been reported under matrix-isolation conditions including but the activation of more inert nitrogen by silylenes remains challenging. Here the authors report on the activation of dinitrogen by silylenes under cryogenic conditions.

Industrial methanol synthesis uses materials based on Cu and ZnO. We present high-resolution imaging of active surfaces which reveals how Zn species are transported at the active Cu interface in diffusion processes controlled by the reactant gas composition.

Using CO and H₂O to electrosynthesize oxygenates is a possible low-carbon synthetic route. Here, the authors study the CO adsorption behavior on Ag catalysts and design a Cu-Ag nanostructure catalyst with a relay mechanism that enhances the electrosynthesis of oxygenates.

Dual blockade therapy is currently being trialled for multiple tumour types, but efficacy is variable. Here, the authors use longitudinal proteomics profiling of 22 patients to develop a predictive model of therapy response.

Achieving acoustic waveguides with low loss, tailorability, and easy fabrication is a considerable challenge. Here, the authors introduce suspended anti-resonant acoustic waveguides with superior confinement and high selectivity of acoustic modes, supporting both forward and backward SBS on chip.

Certain devices require rapid adhesion and detachment, but achieving both can be challenging. Here, the authors report the development of a supramolecular hydrogel with reversible tough adhesion and triggered photodetachment.

Despite the use of amine-functionalized polymers as metal adsorbents, they are generally ineffective at recovering precious metals. Here the authors prepare a star-shaped, hydrazide-functionalized polymer as a recoverable standalone adsorbent with high precious metal adsorption capability/selectivity and practical feasibility.

Developing water compatible synthetic methods for Sulfur(VI) fluoride exchange (SuFEx) chemistry is of paramount importance. Here the authors demonstrate a catalytic dearomative [2+2] photocycloaddition that significantly speeds up the synthesis of heterocyclic alkyl SuFEx hubs, leveraging the unique reactivity at the water-oil interface.

Using computer simulations authors identify the dynamic molecular motions controlling the structural conformation of the TWIK1 ion channel, showing that its ability to transport sodium upon acidification result from the evolution of the classical potassium-selective pore.

Enzymes involve structural flexibility in their function, but understanding enzyme catalysis as connected to protein motions is a major challenge. Here, the authors obtain energetic description of C-H activation in nicotinamide coenzyme-dependent UDP-glucuronic acid C4 epimerase based on temperature kinetic studies and isotope effect measurements.

The heterochromatic 'condensates' may not be conserved across mammals. This study highlights the influence of host genome on nuclear architecture and challenges the hypothesis that heterochromatin and MeCP2 undergo phase separation.

Soil-transmitted helminths (STHs) are major pathogens. Here the authors screen 480 structural families of natural products to find compounds that kill Caenorhabditis elegans specifically when they require rhodoquinone (RQ)-dependent metabolism: they identify several classes of compounds and show some compounds kill adult STHs.

Dual wavelength vat photopolymerization has emerged as a powerful approach to create multimaterial objects but require changing the resin during the printing process. Here, the authors develop a method of dual-wavelength 3D printing that can directly access multicolor parts without requiring changing of resin feedstocks or introduction of new materials during the printing process.

Creating accurate digital twins and controlling nonlinear systems displaying chaotic dynamics is challenging due to high system sensitivity to initial conditions and perturbations. The authors introduce a nonlinear controller for chaotic systems, based on next-generation reservoir computing, with improved accuracy, energy cost, and suitable for implementation with field-programmable gate arrays.

Here, based on a systematic review and meta-analysis, the authors analyze the relationship between vaccine immunogenicity and vaccine protection against mpox and predict the durability of protection after vaccination. This helps inform the optimal vaccine deployment in a health emergency.