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Wang et al. report that the nucleocapsid protein of SARS-CoV-2 forms phase-separated condensates to repress K63-linked ubiquitination and aggregation of mitochondrial antiviral-signalling protein, thus suppressing antiviral immunity.
Patankar et al. identify E-type prostanoid receptor 4 as a negative regulator of tumour necrosis factor signalling and mixed-lineage kinase domain-like pseudokinase activation, thereby suppressing necroptosis of intestinal epithelial cells and promoting resolution of intestinal inflammation.
Wang et al. identify CCM3 as a negative regulator of YAP/TAZ activation and mechanotransduction in focal adhesions, with important roles in controlling mesenchymal/stromal stem cell differentiation and metastasis in mouse models of breast cancer.
Gong et al. uncover a role for the Golgi network in ER-associated endosome fission, showing that a Golgi-derived SEC14L2 compartment mediates ER-associated endosome fission by promoting PtdIns4P to PtdIns3P conversion.
Scheibner et al. demonstrate that, during gastrulation in the mouse, epithelial epiblast progenitors upregulate Foxa2 and form the definitive endoderm independently of a full EMT–MET cycle.
Pérez-González et al. explore the mechanical properties of intestinal organoids, and report the existence of distinct mechanical domains and that cells are pulled out of the central crypt along a gradient of increasing tension.
Yang, Xue et al. demonstrate in intestinal organoids that region-specific cell fates drive actomyosin patterns and modulate luminal osmotic forces to coordinate morphogenesis.
You et al. report single-cell ATAC-seq profiles of periphery immune cells from patients recovered from COVID-19, which reveals a global remodelling of the chromatin accessibility that may contribute to immune memory formation.
Using an unbiased and quantitative proteomic approach, Kugeratski et al. identified the core constituents of exosomes and found that syntenin-1 was the most abundant component, making it a putative universal biomarker.
Xue and colleagues developed LACE-seq to globally profile RNA targets of RNA-binding proteins at single-nucleotide resolution in low-input cells or even single oocytes.
Truong et al. developed a cell-based reporter system, EXSISERS, that enables non-invasive quantification of the protein expression levels of exon-specific isoforms via intein-mediated protein splicing.
Li et al. develop reversible shearing DNA-based tension probes to quantify molecular piconewton-scale forces, estimate the number of mechanically active receptors with single-molecule sensitivity and study mechanisms of force transduction in live cells.
Wang et al. developed a transformer base editor system in which the enzyme activity of the base editor is turned on only at the on-target site, therefore minimizing genome-wide and transcriptome-wide off-target mutations.
Perochon et al. show in Drosophila that gut-derived reactive oxygen species and FGF induce tracheal remodelling after intestinal damage, which in turn promotes intestinal regeneration by activating intestinal stem cells.
Tamamouna, Rahman et al. show that midgut-associated tracheae in Drosophila increase their branching in response to infection, oxidative stress and tumours, driving intestinal regeneration as well as tumour growth.
McGinn et al. show that mechanical stretch in the developing oesophagus promotes the YAP-dependent emergence of a KLF4+ committed basal cell population, revealing how physiological strain triggers the transition to adult homeostasis.
Saichi et al. performed single-cell RNA-seq analysis of antigen-presenting cells (APCs) isolated from the peripheral blood of patients with moderate and severe COVID-19 and uncovered defects in antiviral immune response in specific APC subsets.
Salvi et al. show that GLUT1 is critical for glucose uptake in response to external forces and that ankyrin G is required to retain GLUT1 at sites of E-cadherin force transmission, linking mechanotransduction and glucose uptake.