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Zhu et al. report that, in response to growth signals, ERK undergoes TRIM15-mediated lysine-63-linked ubiquitination, which facilitates ERK interaction with MEK and therefore enhances ERK activity.
Lu, Wang et al. show in mice that the pre-existing embryonic coronary plexus at the inner myocardium undergoes angiogenic expansion through DLL4–NOTCH1 signalling to vascularize the expanding myocardium.
A set of three papers reports that the piRNA pathway is essential for mammalian female fertility based on genetic perturbation experiments performed in golden hamsters.
Davies et al. demonstrate that androgen receptor–targeted therapy induces lineage-plastic transcriptional reprogramming, which is mediated by EZH2 and favours stem cell and neuronal gene networks in treatment-resistant prostate cancer.
A set of three papers reports that the piRNA pathway is essential for mammalian female fertility based on genetic perturbation experiments performed in golden hamsters.
A set of three papers reports that the piRNA pathway is essential for mammalian female fertility based on genetic perturbation experiments performed in golden hamsters.
Benham-Pyle et al. present a single-cell analysis of planarian regeneration and identify rare amputation-specific cell states in the muscle, epidermis and intestine that are required for patterning and stem cell proliferation.
Using human airway organoids and mouse models, Choi et al. show that an IL-1β–Notch–Fosl2 signalling axis regulates the conversion of secretory cells into alveolar type 2 cells after injury.
Constructing a single-cell transcriptional map of primary human epidermal melanocytes, Belote et al. uncover distinct subpopulations of melanocytes, characterize dedifferentiation patterns associated with melanoma prognosis and uncover the unique cellular origins of acral melanoma.
McCarthy, Kaeding et al. identify H3K9me3-heterochromatin proteins that repress heterochromatic genes with implications in hepatic reprogramming and show that ERH is key to global H3K9me3 maintenance in human cells.
Zhao et al. show that ASTE1 is a downstream effector of the shieldin complex, which cleaves the 3′ overhang of DNA double-strand breaks to promote shieldin-dependent non-homologous end-joining.
Using systematic mutagenesis maps, Roberts, Ozkan et al. study how dynamic nucleosome binding of OCT4 modulates chromatin accessibility during cell fate changes and in pluripotency maintenance.
Pierce et al perform genome-wide CRISPR screening and identify LKB1 as a regulator of chromatin accessibility and metastatic progression in lung cancer through a mechanism of SOX17-mediated epigenetic changes.
Zhang et al. report that the systemic mitochondrial unfolded protein response triggered by neuronal mitochondrial stress can be transmitted across multiple generations in Caenorhabditiselegans via a mechanism involving elevation in mitochondrial DNA levels in oocytes.
Soochit et al. report that the residence time of CTCF on chromatin is controlled by its zinc finger 8 domain and determines chromatin organization, DNA methylation and transcriptional robustness in mouse embryonic stem cells.
Claude-Taupin et al. show that ATG9A mediates protection against plasma membrane damage in diverse biological contexts through a mechanism involving IQGAP1 and ESCRTs.
Using gold nanorods and 3D-SPORT to track dynamin-induced fission in live cells, Cheng et al. show that endocytic vesicles undergo a rapid, large rotation before fission, which requires dynamin’s GTPase activity.
Zhang et al. identify ALKBH7 as the demethylase of mitochondrial pre-tRNAs that regulates nascent mitochondrial RNA processing and translation. ALKBH7 loss impairs mitochondrial functions including fatty acid oxidation, leading to obesity.
Clapes et al. show that chemotherapy leads to chromatin reorganization and increased expression of transposable elements, which promote an MDA5-driven inflammatory response that enhances haematopoietic regeneration.
Koester et al. show that, as hair follicle stem cells age, their ability to activate bivalent genes for self-renewal and differentiation is reduced due to increased niche stiffening and subsequent epigenetic effects.