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Shen et al. show that PTENα/β stability is regulated through a ubiquitin-dependent mechanism mediated by USP9X and FBXW11 to modulate H3K4 trimethylation through WDR5 and promote tumour development.
Wang et al. demonstrate that CD9 marks tumour-initiating cells in pancreatic ductal adenocarcinoma (PDAC), and enhances glutamine uptake to promote tumour development in vivo that recapitulates the cellular heterogeneity of primary PDAC.
Aloia, McKie, Vernaz et al. show that during liver damage ductal cells acquire cellular plasticity by undergoing epigenetic remodelling, with TET1-mediated regulation of ErbB–MAPK and YAP–Hippo signalling.
Schmidt et al. show that the translation initiation factor eIF2B5 regulates stress responses and MYC translation to prevent apoptosis, thereby presenting a targetable vulnerability in colorectal cancer.
Brumbaugh, Kim et al. generate mice with inducible H3 K-to-M mutations, which globally inhibit methylation at specific sites, and analyse specific phenotypes and changes in chromatin accessibility and transcriptional programmes.
Jaumouillé et al. show that a talin/vinculin-based molecular clutch mechanically couples the forces generated by Arp2/3- and Dia1-mediated actin polymerization to promote integrin-mediated phagosome formation.
Simonetti et al. uncover an endosomal SNX–BAR sorting complex, ESCPE-1, that coordinates sequence-dependent cargo recognition with the formation of tubulo-vesicular transport carriers for endosomal export.
Karoutas et al. report lamin A/C as a non-histone target for the acetyltransferase MOF. They find that lamin A/C acetylation prevents nuclear envelope rupture and maintains nuclear integrity.
Zhao et al. identify an unexpected role of the nuclear export factor Nxf2 as a partner of Panoramix in mediating piRNA-guided silencing. Nxf2 counteracts Nxf1-centred nuclear RNA transport to prevent the export of transposon transcripts.
Levin-Konigsberg et al. show that resorption of the phagolysosome after degradation of its contents requires transfer of PI4P and tethering to the ER, both mediated by oxysterol-binding protein-related protein 1L (ORP1L).
Pessina et al. report that DNA damage induces the assembly of a functional promoter at double-strand breaks and the transcribed RNAs promote phase separation of damage-response factors such as 53BP1.
Di Giammartino, Kloetgen, Polyzos, Liu et al. probe chromatin organization, enhancer status and transcriptional changes and show that KLF4 acts as a transcriptional regulator and chromatin organizer during induced pluripotent stem cell reprogramming and in pluripotent stem cells.
Wolf et al. show that N-Ank proteins combine their curvature-sensing ankyrin repeat array and N-terminal amphipathic helix to shape membranes, and ankycorbin shapes membrane protrusions in developing neurons.
Lim et al. show that OSBP and VAPA and VAPB deliver cholesterol across ER–lysosome contacts to activate mTORC1. OSBP-mediated cholesterol trafficking activates mTORC1 in a disease model caused by loss of Niemann–Pick C1.
Li et al. find that IFFO1 bridges the core NHEJ factor XRCC4 and lamin A/C, thus reducing the mobility of broken DNA ends to prevent chromosomal translocation in cancer cells.
He and colleagues develop itChIP-seq based on simultaneous cellular indexing and chromatin tagmentation. itChIP-seq is applicable to both low-input and single-cell analyses of chromatin states.
Trivedi et al. find that phase separation of the chromosome passenger complex is essential for its localization and function at the inner centromere during mitosis.
Tan et al. and Siahaan et al. present distinct but complementary data showing that microtubule regulates dynamic condensation of tau molecules, and this in turn affects microtubule biology and function.
Tan et al. and Siahaan et al. present distinct but complementary data showing that microtubule regulates dynamic condensation of tau molecules, and this in turn affects microtubule biology and function.