Reviews & Analysis

This paper presents standards and best practices for reporting genome sequences of uncultivated viruses.

siRNA delivery to the placenta silences the proteins responsible for preeclampsia.

Two methods for measuring cross-reactivity could boost the safety of T-cell therapies.

Screening patient-derived tumor cell cultures against a drug library is a promising adjunct to clinical decision-making.

The assembly of individual genomes from complex microbial communities is improved by sequencing of barcoded fragments.

Massively parallel sequencing of peptides could signal a new era of high-throughput proteomics.

Invasive recordings of human brain activity predict mood fluctuations.

A massive study informed by Design of Experiments uncovers factors that boost protein synthesis.

A new model for representing genomes aims to capture the breadth of genetic diversity in populations.

An engineered probiotic designed to treat a metabolic disease enters clinical trials.

Brendan Frey and colleagues provide a personal overview of the machine learning field and in particular deep learning. They outline the technical challenges in applying machine learning to different types of biological and biomedical data and go on to discuss the challenges in implementing these approaches in the clinical realm, in drug discovery programs and within regulatory agencies.

Machine learning and natural language processing methods are applied to learn from PubMed searches and improve user experience.