Reviews & Analysis

Extensive metabolic engineering of the yeast Yarrowia lipolytica results in a sustainable and commercially viable alternative to fish oil for the supply of eicosapentaenoic acid.

The erroneous links in networks inferred from data can be efficiently eliminated under certain conditions.

Efficient human nuclear-transfer embryo cloning is here at last, prompting renewed efforts to explore hidden variables in the cloning process.

Combinatorial tetramer staining coupled with mass cytometry allows simultaneous detection of T cells specific for a wide array of peptide epitopes.

A method for DNA-templated ligation allows in vitro evolution of organic polymers.

Two studies trace the intracellular trafficking of siRNA delivered by lipid nanoparticles.

Recent advances in understanding the altered metabolism of tumor cells are yielding new therapeutic leads.

A zwitterionic polymer hinders the foreign-body response that leads to fibrotic encapsulation of implants.

Two studies show that circulating tumor cells from breast cancer patients give rise to metastases in mice.

Delineating four categories of field-evolved resistance of pests to Bt crops, through analysis of 77 studies carried out in five continents from 1996 to 2012, should inform future pest management strategies.

Myelinating oligodendrocytes are induced from murine embryonic fibroblasts by transcription factor–mediated reprogramming.

New work fuels the controversy over the role of reactive oxygen species (ROS) in the activity of bactericidal antibiotics.

New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro.

Genetic circuits that process and permanently store information are created with recombinases that flip the orientation of DNA cassettes.

A peptide that enhances autophagy suppresses viral infections and clears protein aggregates.

siRNAs for knocking down target genes in mammalian cells can now be made in bacteria.