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Jeck and Sharpless review recent advances in sequencing, bioinformatics and biochemical analyses that have uncovered numerous circular RNA transcripts in mammalian cells.
Georgiou and colleagues discuss rapidly evolving methods for high-throughput sequencing of the antibody repertoire, and how the resulting data may be applied to answer basic and translational research questions.
Davis and Newell explain how cytometry, and single-cell and sequencing methodologies can be used to characterize human T-cell responses in health and disease.
Delineating four categories of field-evolved resistance of pests to Bt crops, through analysis of 77 studies carried out in five continents from 1996 to 2012, should inform future pest management strategies.