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Repurposing a DNA sequencing instrument for high-throughput analysis of RNA-protein interactions enables detailed analysis of sequence-function relationships.
By incorporating unnatural amino acids into proteins, Elliott et al. label, image and identify proteins in specific cells in a developing fly under physiological conditions.
Mice engineered to express the entire human variable immunoglobulin region enable rapid isolation of high-affinity antibodies specific for antigens of interest.
Yeast-two hybrid screening of E. coli proteins and integration with protein structure and genetic interaction data provides an extensive interactome resource.
Haplotyping of human genomes is improved by augmenting experimental dilution-based haplotyping with statistical analyses, a strategy known until now only as 'Moleculo.'
Zook et al. describe methods for integrating genome variants from five sequencing technologies to characterize the first benchmark sample that can be used to understand accuracy of human whole-genome and targeted sequencing.
Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody heavy and light chains with orthogonal interfaces.