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To increase the tumor specificity of engineered T cells, Kloss et al. design an approach that relies on T cell recognition of two, rather than one, antigens.
A library of DNA constructs enables high-throughput, ligation-free production of transcription activator–like effector (TALE) genes for genetic engineering.
Kwong et al. use nanoparticles coated with protease substrates to generate mass-encoded synthetic biomarkers for sensitive detection of fibrosis and cancer in mice.
High-throughput network maps are used to automatically (or semi-automatically) reconstruct an ontology that recapitulates much of the Gene Ontology and finds additional terms and relations.
The Cuffdiff 2 algorithm improves analysis of RNA-Seq data by accounting for sample-to-sample biological variability and the complexity of transcript isoforms.