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Academic institutions can address the demand for multiskilled individuals who will be competitive in the non-academic job market by establishing a strong career mentorship program.
Administrative patent review procedures are an effective way of correcting erroneously granted biologic patents and may help promote timely drug competition for the benefit of patients and the US healthcare system.
Although CRISPR-based gene therapy for sickle cell disease offers transformative outcomes, drugmakers are striving to develop treatments that are easy to manufacture and can reach much larger numbers of patients.
The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain.
A growing number of companies are testing muscle-building agents to counter the side effects of dramatic weight loss and potentially to preserve lean muscle into old age.
The Iniquitate pipeline assessed the impacts of cell-type imbalance on single-cell RNA sequencing integration through perturbations to dataset balance. The results indicated that cell-type imbalance not only leads to loss of biological signal in the integrated space, but also can change the interpretation of downstream analyses after integration.
New drug approvals reached an all-time high in 2023, with five gene therapies, the first CRISPR–Cas9-edited therapy and a disease-modifying Alzheimer’s drug.