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When applied in large scale to electronic medical record data, the PheWAS approach replicates GWAS associations and reveals potentially new pleiotropic associations.
Arrays of nanoliter wells reduce bias in single-cell genome sequencing, allowing copy number changes in one cell to be detected at unprecedented resolution.
A fusion protein comprising a TALE DNA-targeting domain and the 5-methylcytosine hydroxylase TET1 enables investigation of the function of specific DNA methylation events.