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The pathogenic function of XBP1-expressing astrocytes in experimental autoimmune encephalomyelitis and multiple sclerosis have been studied using FIND-seq, a new method combining microfluidics cytometry, PCR-based detection of nucleic acids and cell sorting for in-depth single-cell transcriptomics analyses of rare cells.
Photocatalytic water splitting with a high solar-to-hydrogen efficiency of more than nine per cent is achieved using pure water, concentrated solar light and an indium gallium nitride photocatalyst.
Structures of the human METTL1–WDR4 complex are revealed, providing molecular insights into substrate recognition, modification and catalytic regulation by the N7-methylguanosine methyltransferase complex.
A study demonstrates full energy–momentum matching, and enhanced interaction, between free electrons and photons through a continuum of flatband resonances, realized in a silicon-on-insulator photonic crystal slab.
The authors show a hysteretic behaviour of superconductivity as a function of electric field in bilayer Td-MoTe2, representing observations of coupled ferroelectricity and superconductivity.
The production of eicosanoids by neutrophils during the neonatal period is necessary for the self-renewal and maintenance of alveolar macrophages during lung development.
Infection of Caenorhabditis elegans by Pseudomonas aeruginosa causes an increased pheromone response via the pheromone receptor STR-44 and increases mating with males, a potential mechanism for promoting adaptation in the host.
A two-dimensional crystalline polymer of C60, termed graphullerene, is synthesized by chemical vapour transport, and mechanically exfoliated to produce molecularly thin flakes with clean interfaces for potential optoelectronic applications.
We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.
A meta-analysis of 1,521 field observations from the past two decades led to the identification of 11 key measures to cost-effectively mitigate nitrogen pollution from global croplands.
A proteogenomic profiling analysis of single cells from the blood and lymph nodes of individuals living with HIV-1 reveals that CD4+ memory T cells harbouring intact provirus show signatures associated with resistance to immune-mediated killing and cell survival.
