Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Ikzf2, which encodes the transcription factor Helios, is identified as a crucial regulator of gene expression in maturing cochlear outer hair cells, and overexpression of Ikzf2 in inner hair cells induces prestin expression and electromotility.
Distinct transcriptional programs are activated during different stages of apoptotic cell engulfment, including a unique program of genes coding for solute carrier proteins and enzymes in the glycolytic pathway.
From 1901 to 2015, missing and disappeared glaciers produced a rise in sea level that may enable the historical budget for global-mean sea-level rise to be closed without recourse to an undiscovered physical process.
TIC236 is an inner-membrane protein that binds to the outer-membrane channel TOC75 to create a long, stable bridge that enables the transport of proteins into chloroplasts.
Mannose reduces the growth of tumour cells by impairing the metabolism of glucose, and enhances cell death when used in combination with conventional chemotherapy.
The plant F-box protein D3 has a C-terminal α-helix that switches between two conformational states, allowing the α/β hydrolase D14 to recruit the transcription repressor D53 for strigolactone-dependent degradation.
New World hantaviruses—which cause a severe human respiratory disease—use surface glycoproteins to bind to the human protocadherin-1 protein and enter endothelial cells in vitro; depleting protocadherin-1 in Syrian golden hamsters largely protects against disease.
Strains of methicillin-resistant Staphylococcus aureus use a prophage-encoded glycosyltransferase to alter the glycosylation of their wall teichoic acid and thereby evade antibody-mediated immune responses.
Genomic, epigenomic and transcriptomic data derived from the Mediterranean amphioxus (Branchiostoma lanceolatum) provide insights into the evolution of the genomic regulatory landscape of chordates.
The gene for the amyloid precursor protein (APP) shows somatic gene recombination in neurons, and the abundance and diversity of APP variants is increased in neurons from individuals with Alzheimer’s disease.
Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.
In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.
Levallois stone-tool technology found at the Guanyindong Cave site in southwest China was dated to approximately 170,000–80,000 years ago, which is much earlier than previously thought.
Modelling the contribution of urbanization to the impacts associated with hurricane Harvey in August 2017 shows that urbanization worsens rainfall and flooding.
An immunoprecipitation-based protocol is developed to analyse DNA methylation in small quantities of circulating cell-free DNA, and can detect and classify cancers in plasma samples from several tumour types.
Neanderthals and Upper Palaeolithic modern humans exhibit similar overall incidences of cranial trauma that are higher for males of both taxa; however, there are species-specific, age-related variations in trauma prevalence.
Hippocampal activity during a period of sleep after memory encoding is crucial for forming long-term memories in rats, even for types of memory considered not to be hippocampus-dependent.
Seismic images of Earth’s crust and uppermost mantle around the Mariana trench show widespread serpentinization, suggesting that much more water is subducted than previously thought.
Introduction of a suicide gene together with a linked cell-division gene to generate a safe-cell system enables the selective elimination of proliferating cells after cell transplantation in mouse models of cell therapy.