Articles

Tumour-derived prostaglandin E₂, signaling through its receptors EP₂ and EP₄, is shown to restrain the responses of tumour-infiltrating stem-like TCF1⁺CD8⁺ T lymphocytes, and modulation of T cell EP₂ and EP₄ can restore anticancer immunity.

A stable tokamak plasma has been demonstrated with a high plasma density and a high energy confinement quality, both of which are simultaneously important for fusion reactors.

A new method for tracking single-cell heteroplasmy, called SCI-LITE, is combined with mitochondrial DNA base editing to reveal principles of heteroplasmy dynamics in dividing cells.

VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models.

We report observations of GRB 231115A, positionally coincident with the starburst galaxy M82, that unambiguously qualify this burst as a giant flare from a magnetar, which is a rare explosive event releasing gamma rays.

BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.

A subset of Macro-positive macrophages is identified to have immunosuppressive functions in the periportal vein zones of the liver to mediate excessive inflammation, and their effects depend on commensal gut bacteria.

A study introduces a novel method to grow single-crystal Cu₂O thin films with selected crystal orientations, highlighting enhanced bulk carrier mobility and carrier diffusion length along the [111] direction that yields Cu₂O photocathodes with improved performance.

By emulating a 2D hard-core Bose–Hubbard lattice using a controllable 4 × 4 array of superconducting qubits, volume-law entanglement scaling as well as area-law scaling at different locations in the energy spectrum are observed.

We show that domain walls in minimally twisted bilayer graphene support exceptionally robust proximity superconductivity in the quantum Hall regime.

A transient perturbation of transcriptional silencing mediated by Polycomb proteins is sufficient to induce an epigenetic cancer cell fate in Drosophila in the absence of driver mutations.

Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.

We develop an optical method that can set and read the state of electrons in the valley polarization of bulk transition metal dichalcogenide semiconductors, with potential utility as digital storage at quantum coherent timescales and application in quantum computing.

Rhodium catalysts confined in zeolite pores exhibit high regioselectivity in the hydroformylation process of propene to high-value n-butanal, surpassing the performance of all heterogeneous and most homogeneous catalysts developed so far.

Single-stranded DNA annealing is driven by RAD52 open rings in association with RPA.

Using complementary multiplicity-edited ¹³C nuclear magnetic resonance spectra, oxidative dearomatization is shown to be a key driver for generating structural diversity during processing of dissolved organic matter and the data also suggest high abundance of OC_qC₃ units.

Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in independently evolved species.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Sea-based optical clocks combining a molecular iodine spectrometer, fibre frequency comb and electronics for monitoring and control demonstrate high precision in a smaller volume than active hydrogen masers.

Prostaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via metabolic impairment and ferroptosis.