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The latest drugs hold fantastic promise for people with severe psoriasis. But where are the treatment options for the far larger number with less serious cases?
The debate over publishing potentially dangerous research on flu viruses would benefit from a closer look at history, argue David Kaiser and Jonathan D. Moreno.
Hagfish embryos show developmental features that contradict the idea that these jawless fish are the most primitive living vertebrates. The findings also help to trace the evolution of vertebrate cranial structure. See Article p.175
Malfunction of presenilin enzymes, which cleave proteins in cell membranes, can lead to Alzheimer's disease. A crystal structure of a microbial presenilin provides insights into the workings of this enzyme family. See Article p.56
Irrespective of an organism's size, the proportional sizes of its parts remain constant. An experimental model reveals size-dependent adjustment of segment formation and gene-expression oscillations in vertebrates. See Letter p.101
A thermal effect predicted more than 40 years ago was nearly forgotten, while a related phenomenon stole the limelight. Now experimentally verified, the effect could spur the development of heat-controlling devices. See Letter p.401
Psoriasis can have a profound impact on patients' emotional and social lives. Christopher Griffiths, a dermatologist at the University of Manchester in the United Kingdom, discusses the disease's psychological fallout and its links with stress.