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Mutations in the maternal copy of the UBE3A gene cause a neurodevelopmental disorder known as Angelman syndrome. Drugs that activate the normally silenced paternal copy of this gene may be of therapeutic value. See Letter p.185
In mammals, molecular clocks regulate transcription and glucose homeostasis. One way they do so is by controlling glucocorticoid-receptor signalling, which suggests that clocks are embedded in liver metabolism. See Letter p.552
President Barack Obama's stance on an emergency contraceptive betrays his promised principles of scientific integrity and sets a troubling precedent for political interference in 'inconvenient' science.
A planetary system has been found in a startlingly tight orbit around an evolved star. The finding challenges the idea that close-in planets are destroyed as their host star evolves. See Letter p.496
The major threats to amphibian species include pandemic disease and changes in climate and in land use. A study of the global distributions of these threats predicts that they will affect most amphibians by 2080. See Letter p.516
The past year has shown how prone a highly networked society is to abrupt change. The future of our complex world, says Philip Ball, depends on becoming resilient to shocks.