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A diazapentadienyl radical featuring a disubstituted carbon centre is discovered allowing the isolation and structural characterization of a stable secondary carbon radical.
Using liquid gallium as an atomically smooth substrate enables the deposition of single-crystal layers of conducting two-dimensional metal–organic frameworks.
d-cyclodextrins are naturally occurring macrocyclic oligosaccharides that act as hosts for hydrophobic guests and are produced on a multi-tonne scale. Now, using chemical synthesis, mirror-image cyclodextrins are produced from l- instead of d-glucose units.
Coupling an exergonic process with an orthogonal, endergonic one has opened the door to drive artificial systems away from equilibrium. Now, this concept is used to bias the outcome of an uphill chemical reaction.
By systematically exploring a large chemical space using automated experimentation, a high-performing organic photocatalyst for hydrogen evolution is discovered.
Artificial intelligence is used to automate the synthesis of single molecules using the tip of a scanning probe microscope, as well as to extract chemical information from these reactions.
Chemical selenylation of sulfur carrier proteins enables enzymatic incorporation of selenium into small molecules, thereby advancing a biocatalytic method for C–Se bond formation and chemoenzymatic selenometabolite synthesis.
Collaboration between synthesis laboratories requires procedures that are reproducible despite differences in equipment. Now, a digital standard for automated chemical synthesis reproduces results between distinct laboratory systems almost half a world apart.
Molecular knots and links retrofitted with iminopyrrole units make these assemblies intrinsically flexible, strengthening their potential application in molecular machinery.
Tailoring of the short-range microenvironment surrounding the active site in ruthenium-based catalyst systems can lead to enhanced overall water splitting.
Using a fully automated closed-loop system, a robotic chemist synthesizes an oxygen-evolution catalyst from Martian meteorites, with implications for the production of catalysts that may underpin human survival on Mars in the future.
Palladium-catalysed enantioselective α-arylation of azlactones and 5H-oxazol-4-ones with aryl halides using Sadphos ligands enables the synthesis of α-aryl quaternary amino acids and glycolic acid derivatives.