Reviews & Analysis

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  • One of the most advanced and challenging topics in modern reticular chemistry is structure multivariation. This Perspective defines the fundamentals of multivariation by considering sequences of chemical species as its true essence, thereby addressing the classification of multivariate structures and presenting new concepts for their analysis and application.

    • Stefano Canossa
    • Zhe Ji
    • Omar M. Yaghi
    Perspective
  • Machine learning is poised to accelerate the development of technologies for a renewable energy future. This Perspective highlights recent advances and in particular proposes Acc(X)eleration Performance Indicators (XPIs) to measure the effectiveness of platforms developed for accelerated energy materials discovery.

    • Zhenpeng Yao
    • Yanwei Lum
    • Zhi Wei Seh
    Perspective
  • This Perspective compares the attributes of nanoparticles versus microparticles as the active electrode material in lithium-ion batteries. We propose that active material particles used in future batteries should be inherently multiscale to capture the best of both worlds.

    • Rishabh Jain
    • Aniruddha Singh Lakhnot
    • Nikhil Koratkar
    Perspective
  • Electron beams in a transmission electron microscope can be used to manipulate matter atom-by-atom. This Review surveys the recent advances and discusses how the further development and integration of machine learning, theory, feedback and instrumentation will push the field forward.

    • Ondrej Dyck
    • Maxim Ziatdinov
    • Sergei V. Kalinin
    Perspective
  • Nucleic acid scaffolds can be precisely interfaced with cellular components, making them interesting materials to probe and program immune cells. In this Perspective, the authors explore nucleic acid technologies for the quantitative detection of single immune cells and for modulating the immune response.

    • Maulik S. Jani
    • Aneesh T. Veetil
    • Yamuna Krishnan
    Perspective
  • The discovery and development of advanced materials are imperative for the clean energy sector. We envision that a closed-loop approach, which combines high-throughput computation, artificial intelligence and advanced robotics, will sizeably reduce the time to deployment and the costs associated with materials development.

    • Daniel P. Tabor
    • Loïc M. Roch
    • Alán Aspuru-Guzik
    Perspective
  • Sodium-ion batteries are an appealing alternative to lithium-ion batteries because they use raw materials that are less expensive, more abundant and less toxic. The background leading to such promises is carefully assessed in terms of cell and battery production, as well as raw material supply risks, for sodium-ion and modern lithium-ion batteries.

    • Christoph Vaalma
    • Daniel Buchholz
    • Stefano Passerini
    Perspective
  • Luminescent solar concentrators (LSCs) offer a unique opportunity to ‘invisibly’ integrate semi-transparent photovoltaic architectural elements, such as electrodeless glazing units, into the building envelope. This Review highlights the advancements making LSCs a realistic technology for near zero-energy buildings, along with the remaining challenges and strategies for further device optimization.

    • Francesco Meinardi
    • Francesco Bruni
    • Sergio Brovelli
    Perspective
  • This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?’

    • Stefan Wilhelm
    • Anthony J. Tavares
    • Warren C. W. Chan
    Perspective