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The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
This Perspective describes the ecosystem of software available for the analysis of tissue images and discusses the need for interactive online guides that help histopathologists make complex images understandable to non-specialists.
This Perspective describes current clinical standards for intraoperative tissue analysis in oncology and discusses potential clinical implementations of intraoperative imaging for pathology-assisted surgery.
Deep surgical wounds can be monitored via conductive multifilament surgical sutures incorporating ‘sensing pledgets’ bearing capacitive sensors operated via harmonic radiofrequency identification.
This Review examines classical methods for the preservation of mammalian biospecimens and the associated mechanisms of cryoinjury and discusses how the methods’ applicability limitations are being addressed.
A microwell chip facilitates the differentiation of aggregates of human induced pluripotent stem cells into pancreatic-duct-like organoids and the characterization of the differentiation process at the single-cell level.
The elastic modulus of the superficial and deep layers of the skin can be dynamically measured via wearable conformal electromagnetic devices consisting of a vibratory actuator and a soft strain-sensing sheet.
Organic electrochemical transistors functionalized with antigen-specific nanobodies can rapidly and specifically detect antigens at attomolar-to-nanomolar levels in bodily fluids.
An efficient protocol for the preparation of DNA libraries for the analysis of methylation patterns in cell-free DNA in plasma enhances the sensitivity of bisulfite sequencing for the early detection of lung cancer.
This Perspective argues that technologies for the neural interfacing of robotic devices with the body that have been clinically tested in humans should be leveraged toward the creation of a new generation of high-performance bionic limbs.
In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.
The restoration of a local chemokine gradient by nanoparticles non-covalently anchored on the surface of systemically administered red blood cells delays cancer progression in mouse models of lung metastasis.
An analysis of the neural coding of speech sounds in anaesthetized gerbils shows that sound-processing algorithms used by hearing aids can degrade the wearer’s ability to discriminate sounds.
The dynamics of multiregional brain networks in response to temporally varying patterns of ongoing direct electrical stimulation can be predicted by modelling, with variabilities in prediction accuracy explained by at-rest functional connectivity.
The time course of tumour responses to immunotherapies can be mathematically predicted on the basis of tumour-growth rates, the rates of immune activation and of tumour–immune-cell interactions, and the efficacy of immune-mediated tumour killing.
This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.
