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Antitumour responses mediated by T helper 17 cells can be induced by intratumourally injected hollow nanoparticles displaying the polysaccharide mannan.
Each of the 13 protein-coding genes in the mouse mitochondrial genome can be ablated using a library of optimized double-stranded-DNA deaminase-derived cytosine base editors.
The targeted delivery of the short-chain fatty acid butyrate to the lower gastrointestinal tract by polymeric nanoscale micelles restores intestinal homeostasis in mouse models of peanut allergy and colitis.
Liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules enable the mapping, via magnetic resonance imaging, of spatial variations of light intensity in illuminated brain tissue in living animals.
Pooled testing for the diagnosis of COVID-19 via isothermal nucleic acid amplification and detection can be automated by using electromagnetically actuated swarms of millimetric magnets to handle droplets of magnetized samples on a microfluidic chip.
Water exchange through the transmembrane channel aquaporin-4 can be measured by conventional dynamic-contrast-enhanced magnetic resonance imaging and is a sensitive biomarker of the proliferation of gliomas and their resistance to chemotherapy.
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood–brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable regions.
Off-the-shelf microphones and earbud components connected to a smartphone can be as effective as an expensive clinical-grade device at measuring otoacoustic emissions to screen for hearing loss.
The flux of autophagosomes in heart tissue can be detected in live mice via the fluorescence and magnetic resonance properties of intravenously injected iron oxide nanoparticles decorated with fluorescent peptides cleavable by lysosomal cathepsins.
An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants, with single-nucleotide specificity.
Assays leveraging the CRISPR-associated enzyme Cas13 and isothermal RNA amplification for the detection of viral RNA are being simplified for point-of-care use.
Weakly supervised deep-learning models for the analysis of whole-slide images from tumour biopsies perform better at prognostic tasks if the models incorporate context from the local microenvironment.
An adhesive hydrogel patch made from off-the-shelf materials seals and aids the healing of gastrointestinal-tissue defects without the need for sutures, as shown with the repair of gastrointestinal leaks in live rats and pigs.
Arrays of ultrasonic transducers arranged hemispherically around the head enable the mapping of haemodynamic changes in the brain via photoacoustic computed tomography at resolutions down to 350 micrometres and 2 seconds.
Volumetric histological imaging of mouse and human tissues without the need for tissue staining or excision can be performed in real time via microscopes leveraging confocally aligned light-sheet illumination.
Deep-learning models trained with images of the external part of the eyes, rather than fundus images of the retina, can also be used to detect severe diabetic conditions, such as diabetic retinopathy.
Freeze-dried genetic circuits can be integrated with textiles for the detection — colorimetric, or via fluorescence or luminescence — of small molecules and nucleic acids from SARS-CoV-2 and other pathogens.
