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A prototype device for performing magnetic-resonance-imaging scans of the brain that integrates a lightweight permanent magnet and low-power gradient coils is suitable for eventual use at the bedside.
Epileptic foci in mice can be better visualized with magnetic resonance imaging by using an intravenously administered nanoparticle that crosses the blood–brain barrier and is sensitive to the abnormal electrical activity of foci.
This Review Article discusses progress in the development of miniaturized and ultralightweight devices for neuroengineering that are wireless, battery-free and fully implantable.
The sustained expression of RNA-targeting Cas9 delivered intramuscularly or systemically by adeno-associated viral vectors eliminates pathogenic foci of expanded-repeat transcripts and reverses muscle-disease phenotypes in mouse models of myotonic dystrophy type 1.
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
By using CRISPR and transposon constructs, pigs have been genetically modified to inactivate endogenous retroviruses and to enhance the compatibility of their organs with the human immune and coagulation systems.
The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
The capacity of mesenchymal stromal cells to promote vascular regeneration in vivo can be enhanced by the combination of specific small-molecule inhibitors and the right waveform of mechanical stretch.
A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.
