Reviews & Analysis

The early stages of the formation of calcific nodules in the aortic valve can be detected by two-photon excited fluorescence microscopy.

A theoretical model of chromatin packing heterogeneity predicts patterns in gene expression and can be used to screen for effective chemotherapeutic adjuvants.

The genetic, epigenetic and transcriptomic profiles of human induced pluripotent stem cells are shaped by the reprogramming route.

Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

Devices made with resorbable polymers and braided materials can accommodate tissue growth in long-bone and heart-valve animal models.

A dendrimer that depletes bioavailable copper as a result of its internal make-up displays powerful anticancer activity in mice, and no observable adverse effects.

Laser light emitted by fluorescently stained human tissue inside a laser cavity can be used to diagnose cancer.

Microchips embedding a magnetic sensor and a radiofrequency transmitter can be localized in the body of a mouse at submillimetre resolution when under a magnetic field.

Causing nanoscale vibrations in bone-marrow stromal cells embedded in a soft collagen gel induces the cells to undergo osteogenic differentiation and mineralization via mechanosensitive signalling pathways.

High-frequency transcranial electric-field oscillations stimulate neural circuits in the deep brain.

Uniform iron oxide nanoparticles with a hydrodynamic diameter of about 12 nm offer high biocompatibility and diagnostic yield as contrast agents for the magnetic resonance imaging of large animals.

A new microsensor can simultaneously track drug pharmacokinetics and pharmacodynamics and the resulting electrophysiological activity in live animals.

The ability to release an anaesthetic from liposomes by applying ultrasound opens up the possibility of managing localized pain on-demand.

Depletion of tumour-associated platelets improves the delivery of anticancer drugs.

Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.

Genetically modified bacteria provide a long-lasting record of intestinal inflammation in mice.

Microscale arrays of protein–polysaccharide clusters enable the functional characterization of human-neutrophil migration.

Cellular biophysical features are identified as predictive biomarkers of ageing.