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A closed-loop and wireless 128-channel neuromodulation device enables electrical stimulation as well as artefact-free long-term recording of local field potentials in the brain of an untethered non-human primate.
An interpretable deep-learning algorithm trained on a small dataset of computed-tomography scans of the head detects acute ICH and classifies the pathology subtypes, with a performance comparable to expert radiologists.
A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.
Focal stimulation of cortical tissue from within a blood vessel via an electrode array mounted on a minimally invasive endovascular stent elicits responses from specific facial muscles and limbs in sheep.
CRISPR–Cas9-mediated genome editing can be activated locally in vivo via an applied magnetic field, after complexation of magnetic nanoparticles with recombinant baculoviral vectors packaging the CRISPR–Cas9 machinery.
DNA origami nanostructures with different shapes can accumulate preferentially in the kidney, with some being renal-protective, as shown in healthy mice and in a mouse model of acute kidney injury.
The systemic administration of haematopoietic stem cells conjugated to anti-PD-1-decorated platelets in leukaemic mice promotes the delivery of the checkpoint inhibitor to the bone marrow and suppresses the growth and recurrence of leukaemia.
Hydrogels incorporating human stromal cells and that after implantation in mice recruit cells from an orthotopic human tumour xenograft enable, after the injection of human immune cells, the study of the evolution of pre-metastatic niches.
Implantable inductively coupled resonant circuits that change their properties in response to electrical or photonic cues and are detectable in magnetic resonance imaging enable the remote sensing of bioluminescence in rodent brains.
A deep-learning algorithm can detect polyps in the colon in real time and with high sensitivity and specificity, according to validation studies with prospectively collected images and videos from colonoscopies performed in 1,138 patients.
The combination of mathematical modelling of tumour tissue, optical imaging of cleared tumours from animal models, and in vivo imaging of vascular perfusion in tumours predicts the tumour uptake and distribution of specific therapeutic agents.
An alert system based on machine learning and trained on surgical data from electronic medical records helps anaesthesiologists prevent hypoxaemia during surgery by providing interpretable real-time predictions.
Bioresorbable pressure sensors with significantly improved operational lifetimes, as exemplified via the monitoring of intracranial pressure in rats for over 25 days, can be similarly accurate to analogous non-resorbable clinical devices.
Adult skeletal muscle, engineered from adult-rat myogenic cells, self-repairs after injury in vitro and when implanted in a mouse dorsal skinfold window-chamber model when the tissue incorporates rat or human macrophages.
The transplantation of skin cells genetically modified to express an enzyme that hydrolyses cocaine into mice leads to long-lasting levels of the enzyme in the circulation and protects the mice from cocaine-seeking behaviour and cocaine overdose.
The reintroduction of PTEN mRNA into PTEN-null prostate cancer cells via encapsulation in polymer–lipid nanoparticles delivered systemically leads to significant inhibition of tumour growth in mouse models of prostate cancer.
An assay that uses machine-learning algorithms on phenotypic-biomarker data from live primary cells predicts post-surgical adverse pathology in prostate-cancer and breast cancer tissue samples from patients.
A point-of-care device that can run on a variety of power inputs enables isothermal nucleic acid quantification for the diagnosis of infectious diseases in resource-limited settings with unreliable electrical power supply.
An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.
Cardiac tissue engineered to enable the modulation of mechanical resistance to tissue contraction facilitates the modelling of genetic pathologies associated with the absence of a thick-filament accessory protein found in striated heart muscle.