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A subcutaneous hydrogel electrostatically entrapping live Zika virus recruited immune cells at the injection site and provided mice with effective protection against a lethal challenge.
A library of renally cleared fluorescence probes that are activated only in the presence of both tumour and leukocyte biomarkers allows for the tracking of specific populations of tumour-infiltrating leukocytes in vivo and in urine.
A Cas9-based gene therapy that replaces expanded CAG repeats in the mutant HTT allele causing Huntington’s disease by a normal CAG repeat led to substantial reductions in neurological symptoms in a pig model of the disease.
A fluorophore with peak excitation and emission wavelengths in the near-infrared window allows for the microscopic imaging of amyloid-β and tau aggregates through the intact skull in mouse models of Alzheimer’s disease.
The sensitivity of conventional lateral-flow assays can be improved by orders of magnitude by using plasmonically active fluorescent gold nanorods as antibody-conjugated labels.
The spatial distribution and placement of antigens in nanoparticle-based cancer vaccines can substantially affect antigen processing, cytokine production, the induction of immune memory and tumour growth.
Dense multi-omics microsampling for the frequent capture and analysis of thousands of molecules in blood alongside physiological information from wearables facilitates the profiling of lifestyle-associated changes in an individual’s health.
Extracellular vesicles encapsulating mRNA encoding for extracellular-matrix collagen and delivered intradermally via microneedles led to the replacement of collagen in the dermis of mice with photoaged skin.
A machine-learning pipeline that mines the entire space of polypeptide-chain sequences can identify potent antimicrobial peptides by integrating tasks that gradually narrow down the search space.